Pioneering studies performed over the past few decades demonstrate links between
epigenetics and type 2 diabetes mellitus (T2DM), the metabolic disorder with the most …

Epigenetic aging clocks have gained significant attention as a tool for predicting age-related
health conditions in clinical and research settings. They have enabled geroscientists to …

Epigenetic ageing, ie, age‐associated changes in DNA methylation patterns, is a sensitive
marker of biological ageing, a major determinant of morbidity and functional decline. We …

People who have a balanced diet and engage in more physical activity live longer, healthier
lives. This study aimed to test the hypothesis that these associations reflect a slowing of …

Abstract α-Klotho (klotho) is a protein involved in suppressing oxidative stress and
inflammation. In animal models, it is reported to underlie numerous aging phenotypes and …

Importance Variation in DNA methylation at specific loci estimates biological age, which is
associated with morbidity, mortality, and social experiences. Aging estimates known as …

The prevalence of obesity has dramatically increased worldwide over the past decades.
Aging-related chronic conditions, such as type 2 diabetes and cardiovascular disease, are …

Background Accelerated aging leads to increasing burdens of chronic diseases in late life,
posing a huge challenge to the society. With two well-developed aging measures (ie …

Background: Hypertension is common in older individuals and is a major risk factor for
cardiovascular disease. Blood DNA methylation profiles have been used to derive metrics of …

Background Obesity is a heritable complex phenotype that can increase the risk of age‐
related outcomes. Biological age can be estimated from DNA methylation (DNAm) using …