Lutein, zeaxanthin, and meso-zeaxanthin: The basic and clinical science underlying carotenoid-based nutritional interventions against ocular disease

PS Bernstein, B Li, PP Vachali, A Gorusupudi… - Progress in retinal and …, 2016 - Elsevier
The human macula uniquely concentrates three carotenoids: lutein, zeaxanthin, and meso-
zeaxanthin. Lutein and zeaxanthin must be obtained from dietary sources such as green …

[HTML][HTML] Non-syndromic retinitis pigmentosa

SK Verbakel, RAC van Huet, CJF Boon… - Progress in retinal and …, 2018 - Elsevier
Retinitis pigmentosa (RP) encompasses a group of inherited retinal dystrophies
characterized by the primary degeneration of rod and cone photoreceptors. RP is a leading …

Genes and mutations causing retinitis pigmentosa

SP Daiger, LS Sullivan, SJ Bowne - Clinical genetics, 2013 - Wiley Online Library
Retinitis pigmentosa (RP) is a heterogeneous set of inherited retinopathies with many
disease‐causing genes, many known mutations, and highly varied clinical consequences …

Neurodegeneration in the diabetic eye: new insights and therapeutic perspectives

R Simo, C Hernández - Trends in Endocrinology & Metabolism, 2014 - cell.com
Diabetic retinopathy (DR), one of the leading causes of preventable blindness, has been
considered a microcirculatory disease of the retina. However, there is emerging evidence to …

The retinal pigment epithelium in health and disease

JR Sparrrow, D Hicks… - Current molecular …, 2010 - ingentaconnect.com
Retinal pigment epithelial cells (RPE) constitute a simple layer of cuboidal cells that are
strategically situated behind the photoreceptor (PR) cells. The inconspicuousness of this …

Chemistry of the retinoid (visual) cycle

PD Kiser, M Golczak, K Palczewski - Chemical reviews, 2014 - ACS Publications
As succinctly summarized by Wolf, 1 lack of vitamin A (all-trans-retinol) was recognized by
ancient Egyptians as causing a visual deficiency involving the retina and cornea that could …

The role of vitamin A in retinal diseases

J Sajovic, A Meglič, D Glavač, Š Markelj… - International journal of …, 2022 - mdpi.com
Vitamin A is an essential fat-soluble vitamin that occurs in various chemical forms. It is
essential for several physiological processes. Either hyper-or hypovitaminosis can be …

Protective factors and the pathogenesis of complications in diabetes

MG Yu, D Gordin, J Fu, K Park, Q Li… - Endocrine …, 2024 - academic.oup.com
Chronic complications of diabetes are due to myriad disorders of numerous metabolic
pathways that are responsible for most of the morbidity and mortality associated with the …

[HTML][HTML] Structure and function of the interphotoreceptor matrix surrounding retinal photoreceptor cells

M Ishikawa, Y Sawada, T Yoshitomi - Experimental eye research, 2015 - Elsevier
The interphotoreceptor matrix (IPM) is a highly organized structure with interconnected
domains surrounding cone and rod photoreceptor cells and extends throughout the …

Autoimmune retinopathy and antiretinal antibodies: a review

DS Grewal, GA Fishman, LM Jampol - Retina, 2014 - journals.lww.com
Purpose: To review the current state for diagnosis and management of autoimmune
retinopathy. Methods: A review of the literature was performed, encompassing autoimmune …