The genetic information of human cells is stored in the context of chromatin, which is
subjected to DNA methylation and various histone modifications. Such a 'language'of …

H2A. Z is a histone variant that provides specific structural and docking-side properties to the
nucleosome, resulting in diverse and specialised molecular and cellular functions. In this …

MacroH2A has established tumour suppressive functions in melanoma and other cancers,
but an unappreciated role in the tumour microenvironment. Using an autochthonous …

Histones are integral components of eukaryotic chromatin that have a pivotal role in the
organization and function of the genome. The dynamic regulation of chromatin involves the …

Herpes simplex virus (HSV-1) progeny form in the nucleus and exit to successfully infect
other cells. Newly formed capsids navigate complex chromatin architecture to reach the …

Epigenetics comprise a diverse array of reversible and dynamic modifications to the cell's
genome without implicating any DNA sequence alterations. Both the external environment …

CENP-A is an essential histone variant that replaces the canonical H3 at the centromeres
and marks these regions epigenetically. The CENP-A nucleosome is the specific building …

Simple Summary The structural unit of chromatin is the nucleosome that is composed of
DNA wrapped around a core of eight histone proteins. Histone variants can replace …

Epigenetics, the inheritance of genomic information independent of DNA sequence, controls
the interpretation of extracellular and intracellular signals in cell homeostasis, proliferation …

Histone chaperones are key regulators of chromatin structure and function. Their frequent
mis-regulation in various cancers can impact tumor initiation and progression. Here, we …