L Yang, P Shi, G Zhao, J Xu, W Peng, J Zhang… - Signal transduction and …, 2020 - nature.com
Since cancer stem cells (CSCs) were first identified in leukemia in 1994, they have been considered promising therapeutic targets for cancer therapy. These cells have self-renewal …
S Li, W Su, H Wu, T Yuan, C Yuan, J Liu… - Nature biomedical …, 2020 - nature.com
Strategies for selectively imaging and delivering drugs to tumours typically leverage differentially upregulated surface molecules on cancer cells. Here, we show that …
CR Reczek, NS Chandel - Annual review of cancer biology, 2017 - annualreviews.org
Reactive oxygen species (ROS), now appreciated for their cellular signaling capabilities, have a dual role in cancer. On the one hand, ROS can promote protumorigenic signaling …
Proliferation is an important part of cancer development and progression. This is manifest by altered expression and/or activity of cell cycle related proteins. Constitutive activation of …
K Banerjee, H Resat - International journal of cancer, 2016 - Wiley Online Library
Signal transducer and activator of transcription 3 (STAT3) is constitutively activated in numerous cancer types, including more than 40% of breast cancers. In contrast to tight …
Inflammation is a fundamental innate immune response to perturbed tissue homeostasis. Chronic inflammatory processes affect all stages of tumour development as well as therapy …
Stemness combines the ability of a cell to perpetuate its lineage, to give rise to differentiated cells, and to interact with its environment to maintain a balance between quiescence …
P Xia, XY Xu - American journal of cancer research, 2015 - ncbi.nlm.nih.gov
Cancer stem cells (CSCs) are a subpopulation of tumor cells that possess unique self- renewal activity and mediate tumor initiation and propagation. The PI3K/Akt/mTOR signaling …
Q Zhao, L Huang, G Qin, Y Qiao, F Ren, C Shen… - Cancer letters, 2021 - Elsevier
Drug resistance remains the major obstacle limiting the effectiveness of chemotherapy for esophageal squamous cell carcinoma (ESCC)[1]. However, how stromal cells cooperate …