The boron advantage: the evolution and diversification of boron's applications in medicinal chemistry

K Messner, B Vuong, GK Tranmer - Pharmaceuticals, 2022 - mdpi.com
In this review, the history of boron's early use in drugs, and the history of the use of boron
functional groups in medicinal chemistry applications are discussed. This includes …

Boron chemicals in diagnosis and therapeutics

BC Das, P Thapa, R Karki, C Schinke… - Future medicinal …, 2013 - Taylor & Francis
Advances in the field of boron chemistry have expanded the application of boron from
material use to medicine. Boron-based drugs represent a new class of molecules that …

Fungal type III polyketide synthases

M Hashimoto, T Nonaka, I Fujii - Natural Product Reports, 2014 - pubs.rsc.org
Covering: 2005 to 2014 This article covers the literature on fungal type III polyketide
synthases (PKSs) published from 2005 to 2014. Since the first discovery of fungal type III …

α-pyrones: Small molecules with versatile structural diversity reflected in multiple pharmacological activities-an update

ZS Bhat, MA Rather, M Maqbool, HUL Lah… - Biomedicine & …, 2017 - Elsevier
The investigations in the chemistry and biology of α-pyrone (2-pyrone) are of vital
importance as they constitute an essential pharmacophore in many naturally occurring and …

Past and future. Current drugs targeting HIV-1 integrase and reverse transcriptase-associated ribonuclease H activity: single and dual active site inhibitors

F Esposito, E Tramontano - Antiviral Chemistry and …, 2014 - journals.sagepub.com
Catalytic HIV type-1 (HIV-1) integrase (IN) and ribonuclease H (RNase H) domains belong
to the polynucleotidyl transferase superfamily and are characterized by highly conserved …

Synthesis, biopharmaceutical characterization, antimicrobial and antioxidant activities of 1-(4′-O-β-d-glucopyranosyloxy-2′-hydroxyphenyl)-3-aryl-propane-1, 3 …

J Sheikh, A Parvez, H Juneja, V Ingle, Z Chohan… - European journal of …, 2011 - Elsevier
This research communication is toward the investigation of the antibacterial, antifungal and
antioxidant activities of the synthesized compounds 1-(4′-O-β-d-glucopyranosyloxy-2 …

[HTML][HTML] Synthetic approaches for BF2-containing adducts of outstanding biological potential. A review

D Delgado, R Abonia - Arabian Journal of Chemistry, 2022 - Elsevier
Organic compounds containing the F or B elements in their structures have recently attracted
the interest of the chemists and medicinal chemists because their improved biological …

Positively-charged, chalcone-hydroxypyrone hybrid ruthenium (II)-arene complexes functionalized with ethacrynic acid: Synthesis, characterizaion, and antitumor …

Y Xuan, Y Yan, X Wei, S Wang, J Zhang, Y Tang… - Journal of Inorganic …, 2025 - Elsevier
A new family of ethacrynic acid-functionalized, chalcone-hydroxypyrone hybrid ruthenium (II)-
arene complexes (4a-4e) have been designed, synthesis and fully characterized by 1 H and …

Ferrocenyl chalcone difluoridoborates inhibit HIV-1 integrase and display low activity towards cancer and endothelial cells

JP Monserrat, RI Al-Safi, KN Tiwari, L Quentin… - Bioorganic & medicinal …, 2011 - Elsevier
We report here the discovery of a potent series of HIV-1 integrase (IN) inhibitors based on
the ferrocenyl chalcone difluoridoborate structure. Ten new compounds have been …

Exploring boron applications in modern agriculture: Antifungal activities and mechanisms of phenylboronic acid derivatives

SS Du, XF Luo, JX An, ZJ Zhang… - Pest Management …, 2023 - Wiley Online Library
Background The unreasonable use of chemical fungicides causes common adverse
consequences that not only affect the environment, but also cause resistance and …