RNA modifications immensely expand the diversity of the transcriptome, thereby influencing
the function, localization, and stability of RNA. One prominent example of an RNA …

Ribonucleotides within the various RNA molecules in eukaryotes are marked with more than
160 distinct covalent chemical modifications. These modifications include those that occur …

Coronaviruses (CoVs) consist of six strains, and the severe acute respiratory syndrome
coronavirus (SARS-CoV), newly found coronavirus (SARS-CoV-2) has rapidly spread …

NAD is a coenzyme central to metabolism that also serves as a 5′-terminal cap for bacterial
and eukaryotic transcripts. Thermal degradation of NAD can generate nicotinamide and …

The occurrence of NAD+ as a non-canonical RNA cap has been demonstrated in diverse
organisms. TIR domain-containing proteins present in all kingdoms of life act in defense …

Mono (ADP-ribose) transferases and mono (ADP-ribosyl) ating sirtuins use NAD+ to perform
the mono (ADP-ribosyl) ation, a simple form of post-translational modification of proteins …

The 5′ cap of eukaryotic mRNA is a hallmark for cellular functions from mRNA stability to
translation. However, the discovery of novel 5′‐terminal RNA caps derived from cellular …

ABSTRACT RNA capping is a prominent RNA modification that influences RNA stability,
metabolism, and function. While it was long limited to the study of the most abundant …

Recent years witnessed the discovery of ubiquitous and diverse 5′-end RNA cap-like
modifications in prokaryotes as well as in eukaryotes. These non-canonical caps include …

All domains of life utilize a diverse set of modified ribonucleotides that can impact the
sequence, structure, function, stability, and the fate of RNAs, as well as their interactions with …