Cirrhosis is usually a late-onset and life-threatening disease characterized by fibrotic
scarring and inflammation that disrupts liver architecture and function. While it is typically the …

Co‐expression of two or more genes at the single‐cell level is usually associated with
functional co‐regulation. While mRNA co‐expression—measured as the correlation in …

Introduction Non-alcoholic steatohepatitis (NASH), an advanced subtype of non-alcoholic
fatty liver disease (NAFLD), has becoming the most important aetiology for end-stage liver …

Animal testing is the current standard for drug and chemicals safety assessment, but
hazards translation to human is uncertain. Human in vitro models can address the species …

Non-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease
worldwide. We performed network analysis to investigate the dysregulated biological …

Polo-like kinase 1 (PLK1) is a regulator of cell mitosis and cytoskeletal dynamics. PLK1
overexpression in liver cancer is associated with tumour progression, metastasis, and …

Expression quantitative trait locus (eQTL) analysis is a popular method of gaining insight
into the function of regulatory variation. While cis-eQTL resources have been instrumental in …

Objective The relationship between epilepsy and glioma has long been widely recognized,
but the mechanisms of interaction remain unclear. This study aimed to investigate the …

Esmaili et al. 1 conducted co-expression network analysis to uncover core homeostatic
modules critical to a broad spectrum of liver diseases in mouse and human. Perturbation …

Co-expression of genes measured with single-cell RNA sequencing is extensively utilized to
understand the principles of gene regulation within and across cell types and species. It is …