HMGA2 as a critical regulator in cancer development

B Mansoori, A Mohammadi, HJ Ditzel, PHG Duijf… - Genes, 2021 - mdpi.com
The high mobility group protein 2 (HMGA2) regulates gene expression by binding to AT-rich
regions of DNA. Akin to other DNA architectural proteins, HMGA2 is highly expressed in …

[HTML][HTML] Oncological role of HMGA2

S Zhang, Q Mo, X Wang - International journal of …, 2019 - spandidos-publications.com
The high mobility group A2 (HMGA2) protein is a non‑histone architectural transcription
factor that modulates the transcription of several genes by binding to AT‑rich sequences in …

[HTML][HTML] Multi-omics analysis of human mesenchymal stem cells shows cell aging that alters immunomodulatory activity through the downregulation of PD-L1

Y Gao, Y Chi, Y Chen, W Wang, H Li, W Zheng… - Nature …, 2023 - nature.com
Mesenchymal stem cells (MSCs) possess potent immunomodulatory activity and have been
extensively investigated for their therapeutic potential in treating inflammatory disorders …

Senescence of mesenchymal stem cells

Y Li, Q Wu, Y Wang, L Li, H Bu… - … journal of molecular …, 2017 - spandidos-publications.com
Mesenchymal stem cells (MSCs) have been used in cell-based therapy for various diseases,
due to their immunomodulatory and inflammatory effects. However, the function of MSCs is …

Lentiviral globin gene therapy with reduced-intensity conditioning in adults with β-thalassemia: a phase 1 trial

F Boulad, A Maggio, X Wang, P Moi, S Acuto, F Kogel… - Nature medicine, 2022 - nature.com
Abstract β-Thalassemias are inherited anemias that are caused by the absent or insufficient
production of the β chain of hemoglobin. Here we report 6–8-year follow-up of four adult …

HMGA genes and proteins in development and evolution

R Vignali, S Marracci - International journal of molecular sciences, 2020 - mdpi.com
HMGA (high mobility group A)(HMGA1 and HMGA2) are small non-histone proteins that can
bind DNA and modify chromatin state, thus modulating the accessibility of regulatory factors …

[HTML][HTML] Actionable cytopathogenic host responses of human alveolar type 2 cells to SARS-CoV-2

RM Hekman, AJ Hume, RK Goel, KM Abo, J Huang… - Molecular cell, 2020 - cell.com
Human transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
causative pathogen of the COVID-19 pandemic, exerts a massive health and socioeconomic …

Rapid and efficient direct conversion of human adult somatic cells into neural stem cells by HMGA2/let-7b

KR Yu, JH Shin, JJ Kim, MG Koog, JY Lee, SW Choi… - Cell reports, 2015 - cell.com
A recent study has suggested that fibroblasts can be converted into mouse-induced neural
stem cells (miNSCs) through the expression of defined factors. However, successful …

[HTML][HTML] Circular RNA NF1-419 enhances autophagy to ameliorate senile dementia by binding Dynamin-1 and Adaptor protein 2 B1 in AD-like mice

C Diling, G Yinrui, Q Longkai, T Xiaocui, L Yadi… - Aging (albany …, 2019 - ncbi.nlm.nih.gov
Recent studies have demonstrated circular RNAs (circRNAs) to be widely expressed and to
have important physiological functions. However, the expression, regulation, and function of …

miR‐330 suppresses EMT and induces apoptosis by downregulating HMGA2 in human colorectal cancer

B Mansoori, A Mohammadi… - Journal of cellular …, 2020 - Wiley Online Library
MicroRNAs (miRNAs) are important molecular regulatorsof cellular signaling and behavior.
They alter gene expression by targeting messenger RNAs, including those encoding …