Following periods of haematopoietic cell stress, such as after chemotherapy, radiotherapy,
infection and transplantation, patient outcomes are linked to the degree of immune …

Interleukin-22 (IL-22) is a recently described IL-10 family cytokine that is produced by T
helper (Th) 17 cells, γδ T cells, NKT cells, and newly described innate lymphoid cells (ILCs) …

Chronic graft-versus-host disease (GVHD) remains a vexing and dangerous complication of
allogeneic stem cell transplantation. Mild forms of chronic GVHD are often manageable with …

Background Approximately 30% of breast cancer patients receive chemotherapy, yet little is
known about influences of current regimens on circulating lymphocyte levels and …

Large numbers of patients now survive long term following stem cell transplantation (SCT).
The late clinical effects of SCT are thus of major concern in the 21st century. Secondary …

Graft-versus-host disease (GVHD) is a common cause of morbidity and mortality after
allogeneic hematopoietic stem cell transplantation. Systemic findings involving the skin …

Delayed T cell recovery and restricted T cell receptor (TCR) diversity after allogeneic
hematopoietic stem cell transplantation (allo-HSCT) are associated with increased risks of …

Although cytomegalovirus (CMV) reactivation has long been implicated in posttransplant
immune dysfunction, the molecular mechanisms that drive this phenomenon remain …

Infection is the leading cause of non-relapse mortality after allogeneic haematopoietic cell
transplantation (HCT). This occurs as a result of dysfunction to the host immune system from …

Since the early beginnings, in the 1950s, hematopoietic stem cell transplantation (HSCT)
has become an established curative treatment for an increasing number of patients with life …