Recently, we presented evidence that high mitochondrial ATP production is a new
therapeutic target for cancer treatment. Using ATP as a biomarker, we isolated the …

Metabolic reprogramming is a hallmark of cancer, which implements a profound metabolic
rewiring in order to support a high proliferation rate and to ensure cell survival in its complex …

Mitochondrial dysfunction is a key feature of cancer and is frequently associated with
increased aggressiveness and metastatic potential. Recent evidence has brought to light a …

To adapt to tumoral environment conditions or even to escape chemotherapy, cells rapidly
reprogram their metabolism to handle adversities and survive. Given the rapid rise of studies …

In mammalian cells, tyrosine phosphorylation is one of the main mechanisms responsible for
regulating signal transduction pathways and key cellular functions. Moreover, recent studies …

Genomics has contributed to the treatment of a fraction of cancer patients. However, there is
a need to profile the proteins that define the phenotype of cancer and its pathogenesis. The …

Cancer cells reprogram energy metabolism by boosting aerobic glycolysis as a main
pathway for the provision of metabolic energy and of precursors for anabolic purposes …

Significance: The mitochondrial oxidative phosphorylation (OXPHOS) system, comprising
the electron transport chain and ATP synthase, generates membrane potential, drives ATP …

The mitochondrial ATP synthase is a multi-subunit enzyme complex located in the inner
mitochondrial membrane which is essential for oxidative phosphorylation under …

The endogenous inhibitor of ATP synthase is a protein of about 10 kDa, known as IF1 which
binds to the catalytic domain of the enzyme during ATP hydrolysis. The main role of IF1 …