Novel Exopolysaccharide from Marine Bacillus subtilis with Broad Potential Biological Activities: Insights into Antioxidant, Anti-Inflammatory, Cytotoxicity, and Anti …

BA Abdel-Wahab, H F. Abd El-Kareem, A Alzamami… - Metabolites, 2022 - mdpi.com
In the presented study, Bacillus subtilis strain AG4 isolated from marine was identified based
on morphological, physiological, phylogenetic characteristics and an examination of 16S …

Novel 1, 3-thiazole analogues with potent activity against breast cancer: A design, synthesis, in vitro, and in silico study

MG Salem, DMA El-Maaty, YIM El-Deen, BH Elesawy… - Molecules, 2022 - mdpi.com
Breast cancer is the most common cancer in women, responsible for over half a million
deaths in 2020. Almost 75% of FDA-approved drugs are mainly nitrogen-and sulfur …

Development of Novel 1,3-Disubstituted-2-Thiohydantoin Analogues with Potent Anti-Inflammatory Activity; In Vitro and In Silico Assessments

SM Khirallah, HMM Ramadan, A Shawky, SH Qahl… - Molecules, 2022 - mdpi.com
Inflammation is the main cause of several autoimmune diseases, including type I diabetes,
rheumatoid arthritis, bullous pemphigoid, paraneoplastic pemphigoid, and multiple …

Unveiling the antitumor potential of novel N-(substituted-phenyl)-8-methoxycoumarin-3-carboxamides as dual inhibitors of VEGFR2 kinase and cytochrome P450 for …

EM Radwan, E Abo-Elabass, AE Abd El-Baky… - Frontiers in …, 2023 - frontiersin.org
Being the sixth most diagnosed cancer and the fourth leading cause of cancer-related
deaths worldwide, liver cancer is considered as a serious disease with a high prevalence …

Antidiabetic potential of novel 1, 3, 5-trisubstituted-2-thioxoimidazloidin-4-one analogues: Insights into α-glucosidase, α-amylase, and antioxidant activities

SM Khirallah, HMM Ramadan, HAA Aladl, NO Ayaz… - Pharmaceuticals, 2022 - mdpi.com
As the ninth leading cause of death globally, diabetes mellitus (DM) is considered to be the
worst chronic metabolic disease requiring an enormous need for healthcare with over 578 …

Assessment of Pharmacological Potential of Novel Exopolysaccharide Isolated from Marine Kocuria sp. Strain AG5: Broad-Spectrum Biological Investigations

SZ Alshawwa, KS Alshallash, A Ghareeb, AM Elazzazy… - Life, 2022 - mdpi.com
With more than 17 clinically approved Drugs and over 20 prodrugs under clinical
investigations, marine bacteria are believed to have a potential supply of innovative …

Novel 2-substituted-quinoxaline analogs with potential antiproliferative activity against breast cancer: insights into cell cycle arrest, topoisomerase II, and EGFR activity

MG Salem, SAA El-Ata, EH Elsayed, SN Mali… - RSC …, 2023 - pubs.rsc.org
Breast cancer is a global health concern, with increasing disease burden and disparities in
access to healthcare. Late diagnosis and limited treatment options in underserved areas …

Vitamin D and swimming exercise prevent obesity in rats under a high-fat diet via targeting FATP4 and TLR4 in the liver and adipose tissue

E Kolieb, SA Maher, MN Shalaby… - International Journal of …, 2022 - mdpi.com
The prevalence of obesity has risen in the last decades, and it has caused massive health
burdens on people's health, especially metabolic and cardiovascular issues. The risk of …

Functions of p120-catenin in physiology and diseases

X Jin, T Lin, Y Wang, X Li, Y Yang - Frontiers in Molecular …, 2024 - frontiersin.org
p120-catenin (p120) plays a vital role in regulating cell-cell adhesion at adherens junctions,
interacting with the juxtamembrane domain (JMD) core region of E-cadherin and regulates …

Insight into the phytochemical profile and antimicrobial activities of Amomum subulatum and Amomum xanthioides: an in vitro and in silico study

MH Alruhaili, MS Almuhayawi, HS Gattan… - Frontiers in Plant …, 2023 - frontiersin.org
Introduction Medicinal plants have been considered as potential source of therapeutics or as
starting materials in drugs formulation. Methods The current study aims to shed light on the …