Tumor microenvironment: barrier or opportunity towards effective cancer therapy
Tumor microenvironment (TME) is a specialized ecosystem of host components, designed
by tumor cells for successful development and metastasis of tumor. With the advent of 3D …
by tumor cells for successful development and metastasis of tumor. With the advent of 3D …
The emerging clinical relevance of genomics in cancer medicine
The combination of next-generation sequencing and advanced computational data analysis
approaches has revolutionized our understanding of the genomic underpinnings of cancer …
approaches has revolutionized our understanding of the genomic underpinnings of cancer …
Multi-omic machine learning predictor of breast cancer therapy response
Breast cancers are complex ecosystems of malignant cells and the tumour
microenvironment. The composition of these tumour ecosystems and interactions within …
microenvironment. The composition of these tumour ecosystems and interactions within …
[HTML][HTML] SARS-CoV-2 spike L452R variant evades cellular immunity and increases infectivity
C Motozono, M Toyoda, J Zahradnik, A Saito… - Cell host & …, 2021 - cell.com
Many SARS-CoV-2 variants with naturally acquired mutations have emerged. These
mutations can affect viral properties such as infectivity and immune resistance. Although the …
mutations can affect viral properties such as infectivity and immune resistance. Although the …
Spatial immunophenotypes predict response to anti-PD1 treatment and capture distinct paths of T cell evasion in triple negative breast cancer
D Hammerl, JWM Martens, M Timmermans… - Nature …, 2021 - nature.com
Only a subgroup of triple-negative breast cancer (TNBC) responds to immune checkpoint
inhibitors (ICI). To better understand lack of response to ICI, we analyze 681 TNBCs for …
inhibitors (ICI). To better understand lack of response to ICI, we analyze 681 TNBCs for …
Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates
Y Simoni, E Becht, M Fehlings, CY Loh, SL Koo… - Nature, 2018 - nature.com
Various forms of immunotherapy, such as checkpoint blockade immunotherapy, are proving
to be effective at restoring T cell-mediated immune responses that can lead to marked and …
to be effective at restoring T cell-mediated immune responses that can lead to marked and …
NetMHCpan-4.0: improved peptide–MHC class I interaction predictions integrating eluted ligand and peptide binding affinity data
Cytotoxic T cells are of central importance in the immune system's response to disease.
They recognize defective cells by binding to peptides presented on the cell surface by MHC …
They recognize defective cells by binding to peptides presented on the cell surface by MHC …
An immunogenic personal neoantigen vaccine for patients with melanoma
Effective anti-tumour immunity in humans has been associated with the presence of T cells
directed at cancer neoantigens, a class of HLA-bound peptides that arise from tumour …
directed at cancer neoantigens, a class of HLA-bound peptides that arise from tumour …
Evolution of neoantigen landscape during immune checkpoint blockade in non–small cell lung cancer
Immune checkpoint inhibitors have shown significant therapeutic responses against tumors
containing increased mutation-associated neoantigen load. We have examined the evolving …
containing increased mutation-associated neoantigen load. We have examined the evolving …
Immunotherapy of non-Hodgkin's lymphoma with a defined ratio of CD8+ and CD4+ CD19-specific chimeric antigen receptor–modified T cells
CD19-specific chimeric antigen receptor (CAR)–modified T cells have antitumor activity in B
cell malignancies, but factors that affect toxicity and efficacy have been difficult to define …
cell malignancies, but factors that affect toxicity and efficacy have been difficult to define …