Syndecan-1 is a cell surface heparan sulfate proteoglycan that binds to many mediators of
disease pathogenesis. Through these molecular interactions, syndecan-1 can modulate …

The expression of proteoglycans (PGs), essential macromolecules of the tumor
microenvironment, is markedly altered during malignant transformation and tumor …

Anchorage of cells to" heparin"–binding domains that are prevalent in extracellular matrix
(ECM) components is thought to occur primarily through the syndecans, a four-member …

Syndecan-1 (SDC1, CD138) is one of the heparan sulfate proteoglycans and is essential for
maintaining normal cell morphology, interacting with the extracellular and intracellular …

Cell surface proteoglycans are known to be important regulators of many aspects of cell
behavior. The principal family of transmembrane proteoglycans is the syndecans, of which …

Syndecan-2 is a transmembrane heparan sulfate proteoglycan whose function at the cell
surface is unclear. In this study, we examined the function of syndecan-2 in colon cancer cell …

Syndecan‐1, a cell surface heparan sulfate proteoglycan, is critically involved in the
differentiation and prognosis of various tumors. In this review, we highlight the synthesis …

Background Recent investigations have demonstrated that the tumor microenvironment,
including tumor-infiltrating lymphocytes (TILs), is an important factor in tumor growth and …

Syndecans are a family of transmembrane heparan sulfate proteoglycans widely expressed
in both developing and adult tissues. Until recently, their role in pathogenesis was largely …

Purpose: Heparan sulfate proteoglycans have been implicated in cancer cell growth,
invasion, metastasis, and angiogenesis. This study was designed to compare their …