Effects of 5-Aza-2′-deoxycytidine (decitabine) on gene expression

RS Seelan, P Mukhopadhyay, MM Pisano… - Drug metabolism …, 2018 - Taylor & Francis
Aza-2'-deoxycytidine (AzaD), also known as Decitabine, is a deoxycytidine analog that is
typically used to activate methylated and silenced genes by promoter demethylation …

Non-coding RNA-mediated epigenetic regulation of liver fibrosis

JJ Yang, H Tao, ZY Deng, C Lu, J Li - Metabolism, 2015 - Elsevier
Hepatic stellate cells (HSC) activation plays a key role in liver fibrosis. Numerous studies
have indicated that non-coding RNAs (ncRNAs) control liver fibrosis and fibroblasts …

Cancer-testis gene biomarkers discovered in colon cancer patients

MH Almutairi, TM Alrubie, AM Alamri, BO Almutairi… - Genes, 2022 - mdpi.com
In Saudi Arabia, colon cancer (CC) is the most prevalent cancer in men and the third most
common cancer in women. Rather than being detected through screening programs, most …

[HTML][HTML] miR-101 reverses hypomethylation of the PRDM16 promoter to disrupt mitochondrial function in astrocytoma cells

Q Lei, X Liu, H Fu, Y Sun, L Wang, G Xu, W Wang… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Our previous report identified PR domain containing 16 (PRDM16), a member of the PR-
domain gene family, as a new methylation associated gene in astrocytoma cells. This …

[HTML][HTML] Epigenetic alterations in the suprachiasmatic nucleus and hippocampus contribute to age-related cognitive decline

SH Deibel, EL Zelinski, RJ Keeley, O Kovalchuk… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Circadian rhythm dysfunction and cognitive decline, specifically memory loss, frequently
accompany natural aging. Circadian rhythms and memory are intertwined, as circadian …

[HTML][HTML] AKAP4 is a circulating biomarker for non-small cell lung cancer

K Gumireddy, A Li, DH Chang, Q Liu, AV Kossenkov… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Cancer testis antigens (CTAs) are widely expressed in tumor tissues, circulating tumor cells
(CTCs) and in cancer derived exosomes that are frequently engulfed by lymphoid cells. To …

[Retracted] Expression Profile of MAGE‐B1 Gene and Its Hypomethylation Activation in Colon Cancer

MH Almutairi, MM Alotaibi, R Alonaizan… - BioMed Research …, 2022 - Wiley Online Library
Cancer‐testis (CT) genes are typically expressed in the testes; however, they have been
linked to aberrant expression in a variety of malignancies. MAGE-B family genes are an …

[HTML][HTML] Identification of MAGE-A family genes in colon cancer patients and their expression mechanism

MH Almutairi, MM Alotaibi, R Alonaizan… - Journal of King Saud …, 2022 - Elsevier
Colon cancer (CC) is a more frequent cancer type among men and is the third one among
women. Cancer testis (CT) genes are classically expressed in the testes during postnatal …

The Expression Patterns of Human Cancer-Testis Genes Are Induced through Epigenetic Drugs in Colon Cancer Cells

MH Almutairi, TM Alrubie, BO Almutairi, AM Alamri… - Pharmaceuticals, 2022 - mdpi.com
Background: The expression of human germline genes is restricted to the germ cells of the
gonads, which produce sperm and eggs. The germline genes involved in testis development …

Differential expression and regulation of ADAD1, DMRTC2, PRSS54, SYCE1, SYCP1, TEX101, TEX48, and TMPRSS12 gene profiles in colon cancer tissues and …

MH Almutairi, TM Alrubie, AT Alshareeda, N Albarakati… - Plos one, 2024 - journals.plos.org
Colon cancer (CC) is a significant cause of death worldwide, particularly in Saudi Arabia. To
increase the accuracy of diagnosis and treatment, it is important to discover new specific …