Next generation of boron neutron capture therapy (BNCT) agents for cancer treatment

P Coghi, J Li, NS Hosmane… - Medicinal Research …, 2023 - Wiley Online Library
Boron neutron capture therapy (BNCT) is one of the most promising treatments among
neutron capture therapies due to its long‐term clinical application and unequivocally …

Bioorthogonal chemistry for prodrug activation in vivo

Q Fu, S Shen, P Sun, Z Gu, Y Bai, X Wang… - Chemical Society …, 2023 - pubs.rsc.org
Prodrugs have emerged as a major strategy for addressing clinical challenges by improving
drug pharmacokinetics, reducing toxicity, and enhancing treatment efficacy. The emergence …

A critical review of radiation therapy: from particle beam therapy (proton, carbon, and BNCT) to beyond

Y Matsumoto, N Fukumitsu, H Ishikawa… - Journal of personalized …, 2021 - mdpi.com
In this paper, we discuss the role of particle therapy—a novel radiation therapy (RT) that has
shown rapid progress and widespread use in recent years—in multidisciplinary treatment …

Optimizing boron neutron capture therapy (BNCT) to treat cancer: an updated review on the latest developments on boron compounds and strategies

A Monti Hughes, N Hu - Cancers, 2023 - mdpi.com
Simple Summary Boron neutron capture therapy (BNCT) is a tumor-selective particle
radiotherapy. It combines preferential boron accumulation in tumors and neutron irradiation …

The basis and advances in clinical application of boron neutron capture therapy

H He, J Li, P Jiang, S Tian, H Wang, R Fan, J Liu… - Radiation …, 2021 - Springer
Boron neutron capture therapy (BNCT) was first proposed as early as 1936, and research on
BNCT has progressed relatively slowly but steadily. BNCT is a potentially useful tool for …

Endocytosis‐Independent and Cancer‐Selective Cytosolic Protein Delivery via Reversible Tagging with LAT1 substrate

Z Zhao, X Liu, M Hou, R Zhou, F Wu, J Yan… - Advanced …, 2022 - Wiley Online Library
Protein drugs targeting intracellular machineries have shown profound therapeutic
potentials, but their clinical utilities are greatly hampered by the lack of efficient cytosolic …

DNA damage and repair dependencies of ionising radiation modalities

E Melia, JL Parsons - Bioscience Reports, 2023 - portlandpress.com
Radiotherapy is utilised in the treatment of∼ 50% of all human cancers, which
predominantly employs photon radiation. However, particle radiotherapy elicits significant …

Tumor Eradication by Boron Neutron Capture Therapy with 10B‐enriched Hexagonal Boron Nitride Nanoparticles Grafted with Poly(Glycerol)

Y Zhang, HG Kang, H Xu, H Luo, M Suzuki… - Advanced …, 2023 - Wiley Online Library
Boron neutron capture therapy (BNCT) has emerged as a treatment modality with high
precision and efficacy of intractable tumors. At the core of effective tumor BNCT are 10B …

Polyglycerol Functionalized 10B Enriched Boron Carbide Nanoparticle as an Effective Bimodal Anticancer Nanosensitizer for Boron Neutron Capture and …

Y Wang, G Reina, HG Kang, X Chen, Y Zou, Y Ishikawa… - Small, 2022 - Wiley Online Library
Boron neutron capture therapy (BNCT) is a non‐invasive cancer treatment with little adverse
effect utilizing nuclear fission of 10B upon neutron irradiation. While neutron source has …

Key biological mechanisms involved in high-LET radiation therapies with a focus on DNA damage and repair

Z Nikitaki, A Velalopoulou, V Zanni, I Tremi… - Expert reviews in …, 2022 - cambridge.org
DNA damage and repair studies are at the core of the radiation biology field and represent
also the fundamental principles informing radiation therapy (RT). DNA damage levels are a …