The ability of the brain to store and process information relies on changing the strength of
connections between neurons. Synaptic facilitation is a form of short-term plasticity that …

Alzheimer's disease (AD) is the most common type of dementia and is characterized by the
accumulation of amyloid (Aβ) plaques and neurofibrillary tangles in the brain. Much attention …

Neurotransmission is sustained by endocytosis and refilling of synaptic vesicles (SVs)
locally within the presynapse. Until recently, a consensus formed that after exocytosis, SVs …

Exocytosis and endocytosis are essential physiological processes and are of prime
importance for brain function. Neurotransmission depends on the Ca 2+-triggered …

Current proteomic studies clarified canonical synaptic proteins that are common to many
types of synapses. However, proteins of diversified functions in a subset of synapses are …

Highlights•Syts also regulate endocytosis and vesicle trafficking, not just
exocytosis.•Neurons as well as glia employ synaptotagmins (Syts) for diverse …

Background Both human and animal studies have shown beneficial effects of physical
exercise on brain health but most tend to be based on aerobic rather than resistance type …

Abstract ALS (Amyotrophic Lateral Sclerosis) is a neurodegenerative disease characterized
by the redistribution of the RNA binding protein TDP-43 in affected neurons: from …

Summary Calcium (Ca 2+) signaling is tightly regulated within a presynaptic bouton. Here,
we visualize Ca 2+ signals within hippocampal presynaptic boutons using GCaMP8s tagged …

Synapses maintain synchronous, asynchronous, and spontaneous modes of
neurotransmission through distinct molecular and biochemical pathways. Traditionally a …