Nitric oxide (NO) is a small gaseous signaling molecule that has important biological effects.
It has been heavily implicated in migraine; and the NO donor, nitroglycerin, has been used …

Migraines constitute a common neurological and headache disorder affecting around 15%
of the world's population. In addition to other mechanisms, neurogenic neuroinflammation …

Background Migraine headache attacks and accompanying sensory augmentation can be
induced by several agents including levcromakalim (LVC), that is also capable of provoking …

Migraine is a debilitating condition that affects hundreds of millions of people worldwide. A
subset of these patients experience chronic migraine, resulting in long‐term disability and a …

Chronic migraine is a debilitating disorder that has a significant impact on patients and
society. Nearly all migraineurs frequently reported light sensitivity during a headache attack …

Background According to the neurovascular theory of migraine, activation of the
trigeminovascular system contributes to the development of migraine. This study examined …

Migraine is a complex neurological disorder characterized by headache and sensory
abnormalities, such as hypersensitivity to light, observed as photophobia. Whilst it is …

Behavioral neuroscience tests such as the Light/Dark Test, the Open Field Test, the Elevated
Plus Maze Test, and the Three Chamber Social Interaction Test have become both essential …

Chronic migraine dramatically affects the quality of life in the migraineurs. This study
examined the effect of chronic cerebrolysin (CBL) treatment on the migraine-associated …

One of the most controversial aspects of the use of animals in science is the production of
pain. Pain is a central ethical concern. The activation of neural pathways involved in the pain …