Ceramides are a heterogeneous group of bioactive membrane sphingolipids that play
specialized regulatory roles in cellular metabolism depending on their characteristic fatty …

Hydroethidine (HE; or dihydroethidium) is the most popular fluorogenic probe used for
detecting intracellular superoxide radical anion. The reaction between superoxide and HE …

Methoxyestradiol (2-ME), a new anticancer agent currently in clinical trials, has been
demonstrated to inhibit superoxide dismutase (SOD) and to induce apoptosis in leukemia …

Cardiovascular diseases (CVDs) are the leading cause of death and illness in Europe and
worldwide, responsible for a staggering 47% of deaths in Europe. Over the past few years …

Reactive oxygen species (ROS) appear to play an important role in regulating growth and
survival of prostate cancer. However, the sources for ROS production in prostate cancer …

Activation of cells by receptor-and nonreceptor-mediated stimuli not only requires a change
in the activity of signaling proteins but also requires a reorganization of the topology of the …

Curcumin is a naturally occurring compound which is known to induce heme oxygenase 1
(HO-1), although the underlying mechanism has not been fully elucidated. This study …

Plasma sphingomyelin concentration is correlated with the development of atherosclerosis.
It has been found to exist in significantly higher concentrations in aortic plaque. This appears …

Metabolic syndrome X and type 2 diabetes share many metabolic and morphological
similarities with Cushing's syndrome, a rare disorder caused by systemic glucocorticoid …

Sphingolipids are bioactive molecules that play either pro-and anti-atherogenic roles in the
formation and maturation of atherosclerotic plaques. Among SLs, ceramide and sphingosine …