Efficacy of intravenous high-dose methotrexate in preventing relapse to the central nervous system in R-CHOP (-like)-treated, high-risk, diffuse large B-cell lymphoma …

ER Tolley, C Lewinter, LM Pedersen… - …, 2024 - pmc.ncbi.nlm.nih.gov
Central nervous system (CNS) relapse in patients with diffuse large B-cell lymphoma
(DLBCL) carries a dismal prognosis and most clinical guidelines recommend CNS …

Circulating Tumor DNA in Diffuse Large B-Cell Lymphoma: from Bench to Bedside?

HJJ Cherng, A Herrera - Current Treatment Options in Oncology, 2024 - Springer
Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma worldwide and
represents an increasingly heterogeneous entity [1, 2] as our understanding of the disease …

Identification, risk factors, and clinical course of CNS relapse in DLBCL patients across 19 prospective phase 2 and 3 trials—a LYSA and GLA/DSHNHL collaboration

F Frontzek, L Renaud, U Dührsen, V Poeschel… - Leukemia, 2024 - nature.com
Progression or relapse in the central nervous system (CNS) remains a rare but mostly fatal
event for patients with diffuse large B-cell lymphoma (DLBCL). In a retrospective analysis of …

IELSG30 phase 2 trial: intravenous and intrathecal CNS prophylaxis in primary testicular diffuse large B-cell lymphoma

A Conconi, A Chiappella, AJM Ferreri… - Blood …, 2024 - ashpublications.org
Primary testicular diffuse large B-cell lymphoma (PTL) is characterized by high risk of
contralateral testis and central nervous system (CNS) relapse. Chemoimmunotherapy with …

Central nervous system prophylaxis in large B‐cell lymphoma: A British Society for Haematology Good Practice Paper

MR Wilson, K Cwynarski, TA Eyre… - British Journal of …, 2024 - Wiley Online Library
Summary This Good Practice Paper provides recommendations for the baseline
investigation, risk stratification and use of prophylactic interventions for patients with large B …

High-grade B-cell lymphoma, not otherwise specified: CNS involvement and outcomes in a multi-institutional series

N Epperla, AS Zayac, DJ Landsburg, AM Bock… - Blood …, 2024 - ashpublications.org
Little is known about the central nervous system (CNS) risk in high-grade B-cell lymphoma,
not otherwise specified (HGBL NOS). Hence, we sought to describe the rates of baseline …

[HTML][HTML] Efficacy and Safety of Ibrutinib in Central Nervous System Lymphoma: A Systematic Review and Meta-Analysis

JH Jaradat, IM Alkhawaldeh, Y Al-Bojoq… - Critical Reviews in …, 2024 - Elsevier
Background Primary central nervous system lymphoma (CNSL) is a rare, aggressive non-
Hodgkin lymphoma confined to the CNS. Although radiation and chemotherapy, particularly …

Dosage of high‐dose methotrexate as CNS prophylaxis in DLBCL: A detailed analysis of toxicity and impact on CNS relapse

MR Wilson, AA Kirkwood… - American …, 2024 - nottingham-repository.worktribe.com
Baseline characteristics and dosing in i-HD-MTX vs EOT groups were compared using
Chisquared tests and Wilcoxon Mann-Whitney tests. Linear regression was used to assess …

Recent updates on central nervous system prophylaxis in patients with high-risk diffuse large B-cell lymphoma

BJG Chua, CE Low, CE Yau, YH Tan, J Chiang… - … Hematology & Oncology, 2024 - Springer
The use of central nervous system (CNS) prophylaxis for patients with diffuse large B-cell
lymphoma (DLBCL) remains controversial. Although uncommon, CNS relapses are …

Incidence and characterization of secondary CNS lymphoma in 1972 patients with DLBCL-a Danish nationwide cohort study

ER Tolley, TH Nielsen, DS Hersby, S Østergaard… - Blood advances, 2024 - Elsevier
Secondary CNS involvement (SCNSL) is a rare manifestation of diffuse large B-cell
lymphoma (DLBCL) with a poor prognosis. We present updated data from a nationwide …