Cell transplantation therapy for spinal cord injury

P Assinck, GJ Duncan, BJ Hilton, JR Plemel… - Nature …, 2017 - nature.com
Spinal cord injury can lead to severe motor, sensory and autonomic dysfunction. Currently,
there is no effective treatment for the injured spinal cord. The transplantation of Schwann …

Therapeutic repair for spinal cord injury: combinatory approaches to address a multifaceted problem

JM Griffin, F Bradke - EMBO molecular medicine, 2020 - embopress.org
The recent years saw the advent of promising preclinical strategies that combat the
devastating effects of a spinal cord injury (SCI) that are progressing towards clinical trials …

Neuronal replacement from endogenous precursors in the adult brain after stroke

A Arvidsson, T Collin, D Kirik, Z Kokaia, O Lindvall - Nature medicine, 2002 - nature.com
In the adult brain, new neurons are continuously generated in the subventricular zone and
dentate gyrus, but it is unknown whether these neurons can replace those lost following …

Grafted human-induced pluripotent stem-cell–derived neurospheres promote motor functional recovery after spinal cord injury in mice

S Nori, Y Okada, A Yasuda, O Tsuji… - Proceedings of the …, 2011 - National Acad Sciences
Once their safety is confirmed, human-induced pluripotent stem cells (hiPSCs), which do not
entail ethical concerns, may become a preferred cell source for regenerative medicine …

Isolation of multipotent adult stem cells from the dermis of mammalian skin

JG Toma, M Akhavan, KJL Fernandes… - Nature cell …, 2001 - nature.com
We describe here the isolation of stem cells from juvenile and adult rodent skin. These cells
derive from the dermis, and clones of individual cells can proliferate and differentiate in …

Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease

JH Kim, JM Auerbach, JA Rodríguez-Gómez, I Velasco… - nature, 2002 - nature.com
Parkinson's disease is a widespread condition caused by the loss of midbrain neurons that
synthesize the neurotransmitter dopamine. Cells derived from the fetal midbrain can modify …

[HTML][HTML] Regeneration of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neural progenitors

H Nakatomi, T Kuriu, S Okabe, S Yamamoto, O Hatano… - Cell, 2002 - cell.com
The adult brain is extremely vulnerable to various insults. The recent discovery of neural
progenitors in adult mammals, however, raises the possibility of repairing damaged tissue …

Solid organ bioprinting: strategies to achieve organ function

AM Jorgensen, JJ Yoo, A Atala - Chemical Reviews, 2020 - ACS Publications
The field of tissue engineering has advanced over the past decade, but the largest impact on
human health should be achieved with the transition of engineered solid organs to the clinic …

Therapeutic potential of appropriately evaluated safe-induced pluripotent stem cells for spinal cord injury

O Tsuji, K Miura, Y Okada, K Fujiyoshi… - Proceedings of the …, 2010 - National Acad Sciences
Various types of induced pluripotent stem (iPS) cells have been established by different
methods, and each type exhibits different biological properties. Before iPS cell-based …

Cell proliferation without neurogenesis in adult primate neocortex

DR Kornack, P Rakic - Science, 2001 - science.org
A recent assertion that new neurons are continually added to the neocortex of adult
macaque monkeys has profound implications for understanding the cellular mechanisms of …