Chromatin features are widely used for genome-scale mapping of enhancers. However,
discriminating active enhancers from other cis-regulatory elements, predicting enhancer …

Targeted protein degradation, with its rapid protein depletion kinetics, allows the
measurement of acute changes in the cell. The auxin-inducible degron (AID) system, rapidly …

The rise of large-scale, sequence-based deep neural networks (DNNs) for predicting gene
expression has introduced challenges in their evaluation and interpretation. Current …

Precise spatiotemporal regulations of gene expression are essential for determining cells'
fates and functions. Enhancers are cis-acting DNA elements that act as periodic …

The enhancer-promoter looping model, in which enhancers activate their target genes via
physical contact, has long dominated the field of gene regulation. However, the ubiquity of …

Transcription is dysregulated in the majority of human cancers. Understanding how normal
transcriptional programs are dysregulated in cancers is crucial to understanding how …