Flaviviruses pose a constant threat to human health. These RNA viruses are transmitted by
the bite of infected mosquitoes and ticks and regularly cause outbreaks. To identify host …

A growing list of Alzheimer's disease (AD) genetic risk factors is being identified, but the
contribution of each variant to disease mechanism remains largely unknown. We have …

A growing community is constructing a next-generation file format (NGFF) for bioimaging to
overcome problems of scalability and heterogeneity. Organized by the Open Microscopy …

Anatomy of large biological specimens is often reconstructed from serially sectioned
volumes imaged by high-resolution microscopy. We developed a method to reassemble a …

Transcription initiation by RNA polymerase II (RNA Pol II) requires preinitiation complex
(PIC) assembly at gene promoters. In the dynamic nucleus, where thousands of promoters …

The heart develops from 2 sources of mesoderm progenitors, the first and second heart field
(FHF and SHF). Using a single-cell transcriptomic assay combined with genetic lineage …

MYC proto-oncogene dysregulation alters metabolism, translation, and other functions in
ways that support tumor induction and maintenance. Although Myc+/− mice are healthier …

The human mitochondrial ribosome contains three [2Fe–2S] clusters whose assembly
pathway, role, and implications for mitochondrial and metabolic diseases are unknown …

To understand biological processes, it is necessary to reveal the molecular heterogeneity of
cells by gaining access to the location and interaction of all biomolecules. Significant …

The molecular mechanisms by which the endosomal sorting complexes required for
transport (ESCRT) proteins contribute to the integrity of the nuclear envelope (NE) barrier …