A double take on bivalent promoters
P Voigt, WW Tee, D Reinberg - Genes & development, 2013 - genesdev.cshlp.org
Histone modifications and chromatin-associated protein complexes are crucially involved in
the control of gene expression, supervising cell fate decisions and differentiation. Many …
the control of gene expression, supervising cell fate decisions and differentiation. Many …
Direct lineage conversions: unnatural but useful?
T Vierbuchen, M Wernig - Nature biotechnology, 2011 - nature.com
Classic experiments such as somatic cell nuclear transfer into oocytes and cell fusion
demonstrated that differentiated cells are not irreversibly committed to their fate. More recent …
demonstrated that differentiated cells are not irreversibly committed to their fate. More recent …
ChEA: transcription factor regulation inferred from integrating genome-wide ChIP-X experiments
Abstract Motivation: Experiments such as ChIP-chip, ChIP-seq, ChIP-PET and DamID (the
four methods referred herein as ChIP-X) are used to profile the binding of transcription …
four methods referred herein as ChIP-X) are used to profile the binding of transcription …
The ground state of embryonic stem cell self-renewal
In the three decades since pluripotent mouse embryonic stem (ES) cells were first described,
they have been derived and maintained by using various empirical combinations of feeder …
they have been derived and maintained by using various empirical combinations of feeder …
[HTML][HTML] Master transcription factors determine cell-type-specific responses to TGF-β signaling
AC Mullen, DA Orlando, JJ Newman, J Lovén… - Cell, 2011 - cell.com
Transforming growth factor beta (TGF-β) signaling, mediated through the transcription
factors Smad2 and Smad3 (Smad2/3), directs different responses in different cell types. Here …
factors Smad2 and Smad3 (Smad2/3), directs different responses in different cell types. Here …
Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators
Combinatorial transcription factor (TF) interactions control cellular phenotypes and,
therefore, underpin stem cell formation, maintenance, and differentiation. Here, we report the …
therefore, underpin stem cell formation, maintenance, and differentiation. Here, we report the …
Dppa2 and Dppa4 directly regulate the Dux-driven zygotic transcriptional program
M Eckersley-Maslin, C Alda-Catalinas… - Genes & …, 2019 - genesdev.cshlp.org
The molecular regulation of zygotic genome activation (ZGA) in mammals remains an
exciting area of research. Primed mouse embryonic stem cells contain a rare subset of “2C …
exciting area of research. Primed mouse embryonic stem cells contain a rare subset of “2C …
Gata3 regulates trophoblast development downstream of Tead4 and in parallel to Cdx2
The mouse blastocyst and stem cells derived from its tissue lineages provide a unique
genetic system for examining the establishment and loss of pluripotency. The transcription …
genetic system for examining the establishment and loss of pluripotency. The transcription …
Zscan4 regulates telomere elongation and genomic stability in ES cells
Exceptional genomic stability is one of the hallmarks of mouse embryonic stem (ES) cells.
However, the genes contributing to this stability remain obscure. We previously identified …
However, the genes contributing to this stability remain obscure. We previously identified …
Induction of pluripotency in mouse somatic cells with lineage specifiers
The reprogramming factors that induce pluripotency have been identified primarily from
embryonic stem cell (ESC)-enriched, pluripotency-associated factors. Here, we report that …
embryonic stem cell (ESC)-enriched, pluripotency-associated factors. Here, we report that …