Virus-like particle vaccines against respiratory viruses and protozoan parasites

KB Chu, FS Quan - 2021 - Springer
The field of vaccinology underwent massive advances over the past decades with the
introduction of virus-like particles (VLPs), a supra-molecular nanoparticle vaccine platform …

Recombinant Vaccinia Virus Expressing Plasmodium berghei Apical Membrane Antigen 1 or Microneme Protein Enhances Protection against P. berghei Infection in …

MJ Kim, KB Chu, SH Lee, HJ Kang, KW Yoon… - Tropical Medicine and …, 2022 - mdpi.com
Recombinant vaccinia viruses (rVV) are effective antigen delivery vectors and are
researched widely as vaccine platforms against numerous diseases. Apical membrane …

Recombinant AMA1 Virus-like Particle Antigen for Serodiagnosis of Toxoplasma gondii Infection

MJ Kim, KB Chu, J Mao, HJ Kang, GD Eom, KW Yoon… - Biomedicines, 2022 - mdpi.com
Toxoplasmosis diagnosis predominantly relies on serology testing via enzyme-linked
immunosorbent assay (ELISA), but these results are highly variable. Consequently, various …

Protective Immunity Induced by Immunization with Baculovirus, Virus-like Particle, and Vaccinia Virus Expressing the AMA1 of Plasmodium berghei

MJ Kim, KB Chu, HJ Kang, KW Yoon, GD Eom, J Mao… - Biomedicines, 2022 - mdpi.com
Heterologous prime–boost immunization regimens using various vaccine platforms
demonstrated promising results against infectious diseases. Here, mice were sequentially …

Protection and Alleviated Inflammation Induced by Virus-like Particle Vaccines Containing Plasmodium berghei MSP-8, MSP-9 and RAP1

SH Lee, KB Chu, HJ Kang, FS Quan - Vaccines, 2022 - mdpi.com
Virus-like particles (VLP) are a highly efficient vaccine platform used to present multiple
antigenic proteins. Merozoite surface protein 8 (MSP-8), 9 (MSP-9) and rhoptry-associated …

Vesicular stomatitis virus-based vaccine targeting plasmodium blood-stage antigens elicits immune response and protects against malaria with protein booster …

Y Sun, X Shi, F Lu, H Fu, Y Yin, J Xu, C Jin… - Frontiers in …, 2022 - frontiersin.org
Merozoite invasion of the erythrocytes in humans is a key step in the pathogenesis of
malaria. The proteins involved in the merozoite invasion could be potential targets for the …

Influenza virus-like particle vaccine containing both apical membrane antigen 1 and microneme-associated antigen proteins of Plasmodium berghei confers …

MJ Kim, KB Chu, HJ Kang, KW Yoon, DH Lee, SH Lee… - BMC immunology, 2022 - Springer
Background Apical membrane antigen 1 (AMA1) and microneme-associated antigen (MIC)
of Plasmodium parasites are important factors involved in host cell invasion. Methods In this …

[HTML][HTML] Virus-like particles expressing microneme-associated antigen of Plasmodium berghei confer better protection than those expressing apical membrane …

MJ Kim, KB Chu, KW Yoon, HJ Kang… - Parasites, Hosts and …, 2024 - ncbi.nlm.nih.gov
Malaria is a global disease affecting a large portion of the world's population. Although
vaccines have recently become available, their efficacies are suboptimal. We generated …