Blood vessel endothelial cells (ECs) have long been known to modulate inflammation by
regulating immune cell trafficking, activation status and function. However, whether the …

On 12 March 2020, the outbreak of coronavirus disease 2019 (COVID-19) was declared a
pandemic by the World Health Organization. As of 4 August 2020, more than 18 million …

The heterogeneity of endothelial cells (ECs) across tissues remains incompletely
inventoried. We constructed an atlas of> 32,000 single-EC transcriptomes from 11 mouse …

The vascular endothelium, a monolayer of endothelial cells (EC), constitutes the inner
cellular lining of arteries, veins and capillaries and therefore is in direct contact with the …

The pathobiology of atherosclerotic disease requires further elucidation to discover new
approaches to address its high morbidity and mortality. To date, over 17 million …

Innate and adaptive immune cell activation and infiltration is the key characteristic of tissue
inflammation. The innate immune system is the front line of host defense in which innate …

Reactive oxygen species (ROS) are critical for the progression of cardiovascular diseases,
inflammations and tumors. However, the mechanisms of how ROS sense metabolic stress …

Single-cell RNA sequencing (scRNA-seq) enables specific profiling of cell populations at
single-cell resolution. The osteoimmunology microenvironment in the occurrence and …

COVID-19 is a primary respiratory illness that is frequently complicated by systemic
involvement of the vasculature. Vascular involvement leads to an array of complications …

In the past, endothelium was thought to be only a mechanical barrier. Today, endothelium is
known to be a tissue regulating vascular tone, cell growth and the interaction between the …