It is only recently that the full importance of nuclear factor-κB (NF-κB) signalling to cancer
development has been understood. Although much attention has focused on the upstream …

A single mouse click on the topic tumor necrosis factor (TNF) in PubMed reveals about 50
000 articles providing one or the other information about this pleiotropic cytokine or its …

The serine/threonine kinase Akt (cellular homolog of murine thymoma virus akt8 oncogene),
also known as PKB (protein kinase B), is activated by lipid products of phosphatidylinositol 3 …

The innate inflammatory immune response must be tightly controlled to avoid damage to the
host. Here, we showed that the tuberous sclerosis complex-mammalian target of rapamycin …

During their lifetime, cells encounter many life or death situations that challenge their very
own existence. Their survival depends on the interplay within a complex yet precisely …

Complexes formed from the nuclear factor κB (NF-κB) family of transcription factors are
ubiquitously expressed and are induced by a diverse array of stimuli. This results in their …

The phosphatase and tensin homolog deleted on chromosome 10 (PTEN) tumor suppressor
is a phosphatase that antagonizes the phosphoinositol-3-kinase/AKT signaling pathway and …

Although global H3K27me3 reprogramming is a hallmark of cancer, no effective therapeutic
strategy for H3K27me3-high malignancies harboring EZH2 WT/WT has yet been …

The activation of NF-κB has been shown to be regulated by multiple phosphorylations of
IκBs and the NF-κB p65 subunit. Here, we characterized the intracellular signaling pathway …

Activation of the IκB kinase (IKK) complex by LPS induces phosphorylation and degradation
of IκBα, leading to the nuclear translocation of NF-κB. Although it is essential for NF-κB …