Bacteria of the genus Legionella are natural pathogens of amoebae that can cause a severe
pneumonia in humans called Legionnaires' Disease. Human disease results from inhalation …

The genus Legionella contains more than 50 species, of which at least 24 have been
associated with human infection. The best-characterized member of the genus, Legionella …

Knowledge that free-living amoebae are capable of causing human disease dates back
some 50 years, prior to which time they were regarded as harmless soil organisms or, at …

The pathogenesis of Legionella pneumophila is derived from its growth within lung
macrophages after aerosols are inhaled from contaminated water sources. Interest in this …

Macrophages and protozoa ingest bacteria by phagocytosis and destroy these microbes
using a conserved pathway that mediates fusion of the phagosome with lysosomes. To …

Abstract Type IV secretion (T4S) systems are ancestrally related to bacterial conjugation
machines. These systems assemble as a translocation channel, and often also as a surface …

Cryptococcus neoformans (Cn) is an encapsulated yeast that is a facultative intracellular
pathogen and a frequent cause of human disease. The interaction of Cn with alveolar …

A large number of proteins transferred by the Legionella pneumophila Dot/Icm system have
been identified by various strategies. With no exceptions, these strategies are based on one …

Rickettsia are best known as strictly intracellular vector‐borne bacteria that cause mild to
severe diseases in humans and other animals. Recent advances in molecular tools and …

We present the genomic sequence of Legionella pneumophila, the bacterial agent of
Legionnaires' disease, a potentially fatal pneumonia acquired from aerosolized …