Recent advances in extracellular vesicle-based organic nanotherapeutic drugs for precision cancer therapy

VN Nguyen, TNT Dao, M Cho, H Jeong… - Coordination Chemistry …, 2023 - Elsevier
Due to the critical limitations of conventional antitumor agents, great efforts have been made
to develop advanced drug delivery systems to enhance the therapeutic outcomes of …

Biogenesis of extracellular vesicles in protozoan parasites: The ESCRT complex in the trafficking fast lane?

A Cruz Camacho, D Alfandari, E Kozela… - PLoS …, 2023 - journals.plos.org
Extracellular vesicles (EVs) provide a central mechanism of cell–cell communication. While
EVs are found in most organisms, their pathogenesis-promoting roles in parasites are of …

Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches

JA Welsh, DCI Goberdhan, L O'Driscoll… - Journal of …, 2024 - Wiley Online Library
Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of
origin and change the functions and phenotypes of other cells. These features indicate …

20S proteasomes secreted by the malaria parasite promote its growth

E Dekel, D Yaffe, I Rosenhek-Goldian… - Nature …, 2021 - nature.com
Mature red blood cells (RBCs) lack internal organelles and canonical defense mechanisms,
making them both a fascinating host cell, in general, and an intriguing choice for the deadly …

Evaluation of splenic accumulation and colocalization of immature reticulocytes and Plasmodium vivax in asymptomatic malaria: A prospective human splenectomy …

S Kho, L Qotrunnada, L Leonardo, B Andries… - PLoS …, 2021 - journals.plos.org
Background A very large biomass of intact asexual-stage malaria parasites accumulates in
the spleen of asymptomatic human individuals infected with Plasmodium vivax. The …

Extracellular Vesicles in Trypanosoma cruzi Infection: Immunomodulatory Effects and Future Perspectives as Potential Control Tools against Chagas Disease

N Cortes-Serra, M Gualdron-Lopez… - Journal of …, 2022 - Wiley Online Library
Chagas disease, caused by the protozoa parasite Trypanosoma cruzi, is a neglected
tropical disease and a major public health problem affecting more than 6 million people …

Extracellular vesicles and immunity: at the crossroads of cell communication

N Aloi, G Drago, S Ruggieri, F Cibella… - International journal of …, 2024 - mdpi.com
Extracellular vesicles (EVs), comprising exosomes and microvesicles, are small
membranous structures secreted by nearly all cell types. They have emerged as crucial …

Malaria parasites release vesicle subpopulations with signatures of different destinations

P Abou Karam, I Rosenhek‐Goldian, T Ziv… - EMBO …, 2022 - embopress.org
Malaria is the most serious mosquito‐borne parasitic disease, caused mainly by the
intracellular parasite Plasmodium falciparum. The parasite invades human red blood cells …

African Plasmodium vivax malaria improbably rare or benign

JK Baird - Trends in Parasitology, 2022 - cell.com
The overwhelming dominance of Duffy blood group negativity among most people living in
sub-Saharan Africa has been considered the basis of their protection from endemic …

NF‐κB/IKK activation by small extracellular vesicles within the SASP

JA Fafián‐Labora, A O'Loghlen - Aging cell, 2021 - Wiley Online Library
Cellular senescence plays an important role in different biological and pathological
conditions. Senescent cells communicate with their microenvironment through a plethora of …