Background: DNA methylation (DNAme) and histone posttranslational modifications (PTMs)
play an integral role in the transcriptional regulation of specific sets of genes and …

DNA modifications add another layer of complexity to the eukaryotic genome to regulate
gene expression, playing critical roles as epigenetic marks. In eukaryotes, the study of DNA …

How transcription is regulated as development commences is fundamental to understand
how the transcriptionally silent mature gametes are reprogrammed. The embryonic genome …

Abstract Background Intracranial aneurysms (IAs) pose a significant and intricate challenge.
Elucidating the interplay between DNA methylation and IA pathogenesis is paramount to …

Histone H3 lysine36 dimethylation (H3K36me2) is generally distributed in the gene body
and euchromatic intergenic regions. However, we found that H3K36me2 is enriched in …

Mammalian fertilization initiates the reprogramming of oocytes and sperm, forming a
totipotent zygote. During this intricate process, the zygotic genome undergoes a maternal-to …

Histone modifications are associated with regulation of gene expression that controls a vast
array of biological processes. Often, these associations are drawn by correlating the …

Abstract DNA methyltransferase 3A (DNMT3A) and its catalytically inactive cofactor DNA
methyltransferase 3-Like (DNMT3L) proteins form functional heterotetramers to deposit DNA …

The mitotic quiescence of prospermatogonia is the event known to occur during genesis of
the male germline and is tied to the development of the spermatogenic lineage. The …

Nuclear receptor-binding SET domain 3, otherwise known as NSD3, is a member of the
group of lysine methyltransferases and is involved in a variety of cellular processes …