Acetylcholinesterase (AChE) inhibitors are widely used for the symptomatic treatment of
Alzheimer's disease and other dementias. More recent use is for myasthenia gravis. Many of …

Highlights•The Caenorhabditis elegans motor circuit has a nearly complete connectome.•
Neurogenetic studies are unveiling a rich and complex set of signaling relationships …

Nervous system maps are of critical importance for understanding how nervous systems
develop and function. We systematically map here all cholinergic neuron types in the male …

Cell-or network-driven oscillators underlie motor rhythmicity. The identity of C. elegans
oscillators remains unknown. Through cell ablation, electrophysiology, and calcium imaging …

Modern recording techniques enable large-scale measurements of neural activity in a
variety of model organisms. The dynamics of neural activity shed light on how organisms …

Random search is a behavioral strategy used by organisms from bacteria to humans to
locate food that is randomly distributed and undetectable at a distance. We investigated this …

The effect of the detailed connectivity of a neural circuit on its function and the resulting
behavior of the organism is a key question in many neural systems. Here, we study the …

Studies of nervous system connectivity, in a wide variety of species and at different scales of
resolution, have identified several highly conserved motifs of network organization. One …

The OpenWorm project has the ambitious goal of producing a highly detailed in silico model
of the nematode Caenorhabditis elegans. A crucial part of this work will be a model of the …

Graph theoretical analyses of nervous systems usually omit the aspect of connection
polarity, due to data insufficiency. The chemical synapse network of Caenorhabditis elegans …