Gene–environment interactions in human health
Gene–environment interactions (G× E), the interplay of genetic variation with environmental
factors, have a pivotal impact on human complex traits and diseases. Statistically, G× E can …
factors, have a pivotal impact on human complex traits and diseases. Statistically, G× E can …
Gene–environment interaction in myopia
X He, SM Li - Ophthalmic and Physiological Optics, 2023 - Wiley Online Library
Myopia is a health issue that has attracted global attention due to its high prevalence and
vision‐threatening complications. It is well known that the onset and progression of myopia …
vision‐threatening complications. It is well known that the onset and progression of myopia …
Modeling interaction and dispersion effects in the analysis of gene-by-environment interaction
Genotype-by-environment interaction (GxE) studies probe heterogeneity in response to risk
factors or interventions. Popular methods for estimation of GxE examine multiplicative …
factors or interventions. Popular methods for estimation of GxE examine multiplicative …
Efficient gene–environment interaction testing through bootstrap aggregating
M Lau, S Kress, T Schikowski, H Schwender - Scientific Reports, 2023 - nature.com
Gene–environment (GxE) interactions are an important and sophisticated component in the
manifestation of complex phenotypes. Simple univariate tests lack statistical power due to …
manifestation of complex phenotypes. Simple univariate tests lack statistical power due to …
Kernel-based gene–environment interaction tests for rare variants with multiple quantitative phenotypes
X Jin, G Shi - Plos one, 2022 - journals.plos.org
Previous studies have suggested that gene–environment interactions (GEIs) between a
common variant and an environmental factor can influence multiple correlated phenotypes …
common variant and an environmental factor can influence multiple correlated phenotypes …
A multivariate approach to joint testing of main genetic and gene-environment interaction effects
S Mishra, A Majumdar - bioRxiv, 2024 - biorxiv.org
Gene-environment (GxE) interactions crucially contribute to complex phenotypes. The
statistical power of a GxE interaction study is limited mainly due to weak GxE interaction …
statistical power of a GxE interaction study is limited mainly due to weak GxE interaction …
[PDF][PDF] Heteroscedastic regression modeling elucidates gene-by-environment interaction
Genotype-by-environment interaction (GxE) occurs when the size of a genetic effect varies
systematically across levels of the environment and when the size of an environmental effect …
systematically across levels of the environment and when the size of an environmental effect …
Distinguishing between interaction and dispersion effects in the analysis of gene-environment interaction
Genotype-by-environment interaction (GxE) occurs when the size of a genetic effect varies
systematically across levels of the environment and when the size of an environmental effect …
systematically across levels of the environment and when the size of an environmental effect …