After more than a century from its discovery, valproic acid (VPA) still represents one of the
most efficient antiepileptic drugs (AEDs). Pre and post-synaptic effects of VPA depend on a …

Since the serendipitous discovery of its anticonvulsant properties more than 50 years ago,
valproic acid has become established as an effective broad-spectrum antiepileptic drug that …

Neural tube defects (NTDs) are common birth defects and contribute to life-long disabilities,
high medical care costs, and perinatal and child mortality. This review is a primer on …

Background Drug safety has the highest priority in the treatment of pregnant women, as any
effect on fetal development will not be immediately evident, and the harm that ensues may …

Antiepileptic drugs (AEDs) are among the most common teratogenic drugs prescribed to
women of childbearing age. AEDs can induce both anatomical (malformations) and …

All psychiatric disorders have suffered from a dearth of truly novel pharmacological
interventions. In bipolar disorder, lithium remains a mainstay of treatment, six decades since …

Objective The purpose of this review was to identify risk factors, prognostic factors, and
comorbidities associated with common spinal disorders. Methods A scoping review of the …

It is challenging to balance the fetal risks associated with the use of antiepileptic drugs
(AEDs) against maternal and fetal risks of seizure worsening, and therefore it is very …

Psychopharmacotherapy in Pregnancy and Breastfeeding : Obstetrical & Gynecological Survey
Psychopharmacotherapy in Pregnancy and Breastfeeding : Obstetrical & Gynecological …

Background: The etiology of congenital heart disease (CHD) has been extensively studied
in the past decades. Therefore, it is critical to clarify clear hierarchies of evidence between …