Glioblastoma multiforme: Pathogenesis and treatment

C Alifieris, DT Trafalis - Pharmacology & therapeutics, 2015 - Elsevier
Abstract Each year, about 5–6 cases out of 100,000 people are diagnosed with primary
malignant brain tumors, of which about 80% are malignant gliomas (MGs). Glioblastoma …

Glioblastoma

HG Wirsching, M Weller - Malignant Brain Tumors: State-of-the-Art …, 2017 - Springer
Glioblastoma is the most aggressive and the most common primary malignant brain tumor in
adults. Risk factors for glioblastoma are widely elusive and the clinical course is generally …

Malignant gliomas in adults

PY Wen, S Kesari - New England Journal of Medicine, 2008 - Mass Medical Soc
Malignant gliomas, the most common type of primary brain tumor in adults, are associated
with disproportionate cancer-related morbidity and mortality. Recently, there have been …

[HTML][HTML] Advances and challenges in the treatment of glioblastoma: a clinician's perspective

MM Mrugala - Discovery medicine, 2013 - discoverymedicine.com
Glioblastoma (GBM) is the most deadly form of human cancer. Most patients diagnosed with
this WHO grade IV malignant glioma survive about 12 months. Despite international efforts …

Reirradiation tolerance of the human brain

R Mayer, P Sminia - International Journal of Radiation Oncology* Biology …, 2008 - Elsevier
PURPOSE: To give an overview of current available clinical data on reirradiation of glioma
with respect to the tolerance dose of normal brain tissue. METHODS AND MATERIALS …

Identification of SOX2 as a novel glioma-associated antigen and potential target for T cell-based immunotherapy

M Schmitz, A Temme, V Senner, R Ebner… - British journal of …, 2007 - nature.com
Prognosis for patients suffering from malignant glioma has not substantially improved.
Specific immunotherapy as a novel treatment concept critically depends on target antigens …

A role for glutamate in growth and invasion of primary brain tumors

H Sontheimer - Journal of neurochemistry, 2008 - Wiley Online Library
The vast majority of primary brain tumors derive from glial cells and are collectively called
gliomas. While, they share some genetic mutations with other cancers, they do present with …

Insights into molecular therapy of glioma: current challenges and next generation blueprint

Y Rajesh, I Pal, P Banik, S Chakraborty… - Acta pharmacologica …, 2017 - nature.com
Glioma accounts for the majority of human brain tumors. With prevailing treatment regimens,
the patients have poor survival rates. In spite of current development in mainstream glioma …

Current status of local therapy in malignant gliomas—a clinical review of three selected approaches

TA Juratli, G Schackert, D Krex - Pharmacology & therapeutics, 2013 - Elsevier
Malignant gliomas are the most frequently occurring, devastating primary brain tumors, and
are coupled with a poor survival rate. Despite the fact that complete neurosurgical resection …

Response criteria for glioma

AG Sorensen, TT Batchelor, PY Wen… - Nature Clinical Practice …, 2008 - nature.com
The current method for assessing the response to therapy of glial tumors was described by
Macdonald et al. in 1990. Under this paradigm, response categorization is determined on …