Unadjuvanted intranasal spike vaccine elicits protective mucosal immunity against sarbecoviruses
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has
highlighted the need for vaccines that not only prevent disease but also prevent …
highlighted the need for vaccines that not only prevent disease but also prevent …
Riemannian score-based generative modelling
Score-based generative models (SGMs) are a powerful class of generative models that
exhibit remarkable empirical performance. Score-based generative modelling (SGM) …
exhibit remarkable empirical performance. Score-based generative modelling (SGM) …
Genome-wide CRISPR screens reveal host factors critical for SARS-CoV-2 infection
Identification of host genes essential for severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) infection may reveal novel therapeutic targets and inform our understanding …
(SARS-CoV-2) infection may reveal novel therapeutic targets and inform our understanding …
Advancements in Nipah virus treatment: Analysis of current progress in vaccines, antivirals, and therapeutics
Nipah virus (NiV) causes severe encephalitis in humans. Three NiV strains NiV‐Malaysia
(NiVM), NiV Bangladesh (NiVB), and NiV India (NiVI reported in 2019) have been circulating …
(NiVM), NiV Bangladesh (NiVB), and NiV India (NiVI reported in 2019) have been circulating …
Nonsteroidal anti-inflammatory drugs dampen the cytokine and antibody response to SARS-CoV-2 infection
Identifying drugs that regulate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) infection and its symptoms has been a pressing area of investigation during the …
2) infection and its symptoms has been a pressing area of investigation during the …
Pharmacological disruption of mSWI/SNF complex activity restricts SARS-CoV-2 infection
Identification of host determinants of coronavirus infection informs mechanisms of viral
pathogenesis and can provide new drug targets. Here we demonstrate that mammalian …
pathogenesis and can provide new drug targets. Here we demonstrate that mammalian …
Adaptive immune determinants of viral clearance and protection in mouse models of SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused more than 160
million infections and more than 3 million deaths worldwide. Although effective vaccines are …
million infections and more than 3 million deaths worldwide. Although effective vaccines are …
Single-dose mucosal replicon-particle vaccine protects against lethal Nipah virus infection up to 3 days after vaccination
SR Welch, JR Spengler, SC Genzer… - Science …, 2023 - science.org
Nipah virus (NiV) causes a highly lethal disease in humans who present with acute
respiratory or neurological signs. No vaccines against NiV have been approved to date …
respiratory or neurological signs. No vaccines against NiV have been approved to date …
Differential Features of Fusion Activation within the Paramyxoviridae
KD Azarm, B Lee - Viruses, 2020 - mdpi.com
Paramyxovirus (PMV) entry requires the coordinated action of two envelope glycoproteins,
the receptor binding protein (RBP) and fusion protein (F). The sequence of events that …
the receptor binding protein (RBP) and fusion protein (F). The sequence of events that …
Architecture and antigenicity of the Nipah virus attachment glycoprotein
Z Wang - Biophysical Journal, 2022 - cell.com
Nipah virus (NiV) and Hendra virus (HeV) are highly pathogenic zoonotic henipaviruses
(HNVs) responsible for recurrent outbreaks of encephalitis and respiratory illness. As the …
(HNVs) responsible for recurrent outbreaks of encephalitis and respiratory illness. As the …