Abstract The Wisconsin Registry for Alzheimer's Prevention is a longitudinal observational
cohort study enriched with persons with a parental history (PH) of probable Alzheimer's …

Importance Converging evidence suggests that Alzheimer disease (AD) involves insulin
signaling impairment. Patients with AD and individuals at risk for AD show reduced glucose …

Objective: To identify a cognitive composite that is sensitive to tracking preclinical
Alzheimer's disease decline to be used as a primary end point in treatment trials. Method …

Objective: To examine whether engagement in physical activity might favorably alter the age-
dependent evolution of Alzheimer disease (AD)-related brain and cognitive changes in a …

Introduction Longitudinal cohort studies of cognitive aging must confront several sources of
within-person variability in scores. In this article, we compare several neuropsychological …

Objective To determine the nature and extent of minor neuropsychological deficits in
patients with subjective cognitive decline (SCD) and their association with CSF biomarkers …

Polygenic risk scores (PRSs) have been used to combine the effects of variants with small
effects identified by genome-wide association studies. We explore the potential for using …

Higher occupational attainment has previously been associated with increased Alzheimer's
disease (AD) neuropathology when individuals are matched for cognitive function, indicating …

Abstract Background Subjective memory complaints (SMCs) represent an individual's
perception of subtle changes in memory in the absence of objective impairment in memory …

Background Metabolic syndrome (MetS)—a cluster of cardiovascular risk factors—is linked
with cognitive decline and dementia. However, the brain changes underlying this link are …