The Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-
associated (Cas) system is widely used as a genome-editing tool in various organisms …

Filamentous fungi possess the capacity to produce a wide array of secondary metabolites
with diverse biological activities and structures, such as lovastatin and swainsonine. With the …

FlyBase provides a centralized resource for the genetic and genomic data of Drosophila
melanogaster. As FlyBase enters our fourth decade of service to the research community …

Critical periods—brief intervals during which neural circuits can be modified by activity—are
necessary for proper neural circuit assembly. Extended critical periods are associated with …

Abstract The Transgenic RNAi Project (TRiP), a Drosophila melanogaster functional
genomics platform at Harvard Medical School, was initiated in 2008 to generate and …

Transcriptional effectors are protein domains known to activate or repress gene expression;
however, a systematic understanding of which effector domains regulate transcription across …

For more than 100 years, the fruit fly, Drosophila melanogaster, has served as a powerful
model organism for biological and biomedical research due to its many genetic and …

CRISPR-Cas-based transcriptional activators allow genetic engineers to specifically induce
expression of one or many target genes in trans. Here we review the many design variations …

This study addresses the microbial risks associated with Underground Hydrogen Storage
(UHS), a critical component in the transition towards renewable energy systems, by …

Animals perform or terminate particular behaviors by integrating external cues and internal
states through neural circuits. Identifying neural substrates and their molecular modulators …