An increase in fat mass is considered to be an important risk factor for the worldwide
increase in type 2 diabetes and cardiovascular disease. However, for a given fat mass, there …

Obesity, the major cause of the current global epidemic of type 2 diabetes (T2D), induces
insulin resistance in peripheral insulin target tissues. Several mechanisms have been …

Obesity and diabetes now considered global epidemics. The prevalence rates of diabetes
are increasing in parallel with the rates of obesity and the strong connection between these …

Obesity is one of the main risk factors for type 2 diabetes (T2D), representing a major
worldwide health crisis. Modest weight-loss (≥ 5% but< 10%) can minimize and reduce …

Recent evidence from large prospective US and European cohort studies and from
metaanalyses of epidemiological studies indicates that the long-term consumption of …

Introducción y objetivos Según el análisis de 2013 del Institute of Health Metrics, valores
elevados de índice de masa corporal son el primer factor de riesgo de carga de enfermedad …

Body fat distribution is a heritable risk factor for cardiovascular and metabolic disease. In
humans, rare Inhibin beta E (INHBE, activin E) loss-of-function variants are associated with a …

Obesity is a chronic disease that has already reached pandemic proportions and is
becoming one of the leading causes of death and disability worldwide. A comprehensive …

Background Excess adiposity is associated with cardiovascular disease (CVD) risk factors
such as hypertension, diabetes mellitus and dyslipidemia. Amongst the various measures of …

The adipose tissue is crucial in regulating insulin sensitivity and risk for diabetes through its
lipid storage capacity and thermogenic and endocrine functions. Subcutaneous adipose …