Development of a potent cyclic peptide inhibitor of the nNOS/PSD-95 interaction
JR Balboa, DJ Essig, S Ma, N Karer… - Journal of Medicinal …, 2022 - ACS Publications
The complex between the N-methyl-d-aspartate receptor (NMDAR), neuronal nitric oxide
synthase (nNOS), and the postsynaptic density protein-95 (PSD-95) is an attractive …
synthase (nNOS), and the postsynaptic density protein-95 (PSD-95) is an attractive …
Dishevelled2 activates WGEF via its interaction with a unique internal peptide motif of the GEF
A Omble, S Mahajan, A Bhoite, K Kulkarni - Communications Biology, 2024 - nature.com
The Wnt-planar cell polarity (Wnt-PCP) pathway is crucial in establishing cell polarity during
development and tissue homoeostasis. This pathway is found to be dysregulated in many …
development and tissue homoeostasis. This pathway is found to be dysregulated in many …
Unconventional PDZ Recognition Revealed in α7 nAChR-PICK1 Complexes
PDZ domains are modular domains that conventionally bind to C terminal or internal motifs
of target proteins to control cellular functions through the regulation of protein complex …
of target proteins to control cellular functions through the regulation of protein complex …
AIDA-1/ANKS1B Binds to the SynGAP Family RasGAPs with High Affinity and Specificity
Abstract AIDA-1, encoded by ANKS1B, is an abundant postsynaptic scaffold protein
essential for brain development. Mutations of ANKS1B are closely associated with various …
essential for brain development. Mutations of ANKS1B are closely associated with various …
Simulated complexes formed from a set of postsynaptic proteins suggest a localised effect of a hypomorphic Shank mutation
M Miski, Á Weber, K Fekete-Molnár… - BMC neuroscience, 2024 - Springer
Background The postsynaptic density is an elaborate protein network beneath the
postsynaptic membrane involved in the molecular processes underlying learning and …
postsynaptic membrane involved in the molecular processes underlying learning and …
[PDF][PDF] Biophysical and structural analyses of the interaction between the SHANK1 PDZ domain and an internal SLiM
Y Li, CH Trinh, A Acevedo-Jake, D Gimenez… - Biochemical …, 2024 - portlandpress.com
The PDZ (Postsynaptic density protein-95 [PSD-95]/Discs-large) domain, prevalent as a
recognition module, has attracted significant attention given its ability to specifically …
recognition module, has attracted significant attention given its ability to specifically …
An Unconventional Ligand for Scribble PDZ-4 Domain Mediates Its Interaction with Dusp26
PDZ domains are involved in many cellular processes and are key regulators of the cell
physiology. A huge number of studies have investigated the binding specificity of PDZ …
physiology. A huge number of studies have investigated the binding specificity of PDZ …
Resonance assignment of the Shank1 PDZ domain
A Sánta, A Czajlik, G Batta, B Péterfia… - Biomolecular NMR …, 2022 - Springer
Shank proteins are among the most abundant and well-studied postsynaptic scaffold
proteins. Their PDZ domain has unique characteristics as one of its loop regions flanking the …
proteins. Their PDZ domain has unique characteristics as one of its loop regions flanking the …