Neutrophil degranulation, plasticity, and cancer metastasis

F Mollinedo - Trends in immunology, 2019 - cell.com
Neutrophils are the first responders to inflammation and infection. Recently, an elevated
neutrophil-to-lymphocyte ratio has generally become a prognostic indicator of poor overall …

Metabolic insight of neutrophils in health and disease

S Kumar, M Dikshit - Frontiers in immunology, 2019 - frontiersin.org
Neutrophils are the most abundant, short lived, and terminally differentiated leukocytes with
distinct tiers of arsenals to counter pathogens. Neutrophils were traditionally considered …

Neutrophil transendothelial migration: updates and new perspectives

MD Filippi - Blood, The Journal of the American Society of …, 2019 - ashpublications.org
Neutrophils represent the first line of cellular defense against invading microorganism by
rapidly moving across the blood–endothelial cell (EC) barrier and exerting effector cell …

Mechanism of diapedesis: importance of the transcellular route

MD Filippi - Advances in immunology, 2016 - Elsevier
The neutrophil transmigration across the blood endothelial cell barrier represents the
prerequisite step of innate inflammation. Neutrophil recruitment to inflamed tissues occurs in …

Macrophage-epithelial interactions in pulmonary alveoli

J Bhattacharya, K Westphalen - Seminars in immunopathology, 2016 - Springer
Alveolar macrophages have been investigated for years by approaches involving
macrophage extraction from the lung by bronchoalveolar lavage, or by cell removal from …

Shp1 function in myeloid cells

CL Abram, CA Lowell - Journal of Leukocyte Biology, 2017 - academic.oup.com
The motheaten mouse was first described in 1975 as a model of systemic inflammation and
autoimmunity, as a result of immune system dysregulation. The phenotype was later …

The molecular mechanisms of extracellular matrix-derived hydrogel therapy in idiopathic pulmonary fibrosis models

D Evangelista-Leite, ACO Carreira, MY Nishiyama… - Biomaterials, 2023 - Elsevier
Abstract Idiopathic Pulmonary Fibrosis (IPF) is a progressively debilitating lung condition
characterized by oxidative stress, cell phenotype shifts, and excessive extracellular matrix …

The interplay between integrins and immune cells as a regulator in cancer immunology

Q Zhang, S Zhang, J Chen, Z Xie - International Journal of Molecular …, 2023 - mdpi.com
Integrins are a group of heterodimers consisting of α and β subunits that mediate a variety of
physiological activities of immune cells, including cell migration, adhesion, proliferation …

Staphylococcus aureus drives expansion of low-density neutrophils in diabetic mice

TS Cohen, V Takahashi, J Bonnell… - The Journal of …, 2019 - Am Soc Clin Investig
Diabetic individuals are at considerable risk for invasive infection by Staphylococcus aureus,
however, the mechanisms underlying this enhanced susceptibility to infection are unclear …

Lophatherum gracile Brongn. attenuates neutrophilic inflammation through inhibition of JNK and calcium

KH Lai, PJ Chen, CC Chen, SH Yang… - Journal of …, 2021 - Elsevier
Abstract Ethnopharmacological relevance Lophatherum gracile Brongn.(L. gracile) has
been long used in traditional herbal medicine to clinically clear heat, disinhibit dampness …