SUMOylation is a reversible post-translational modification which has emerged as a crucial
molecular regulatory mechanism, involved in the regulation of DNA damage repair, immune …

A decade has passed since SUMO (small ubiquitin-related modifier) was discovered to be a
reversible post-translational protein modifier. During this time many enzymes that participate …

Protein conjugation with Small ubiquitin-like modifier (SUMOylation) has critical roles during
cell cycle progression. Many important cell cycle regulators, including many oncogenes and …

Small ubiquitin-like modifier (SUMO) family proteins regulate target-protein functions by post-
translational modification. However, a potent and selective inhibitor targeting the SUMO …

Objective Pancreatic ductal adenocarcinoma (PDAC) has the characteristics of high-density
desmoplastic stroma, a distinctive immunosuppressive microenvironment and is profoundly …

Ubiquitin and ubiquitin-like proteins (Ubls) are signalling messengers that control many
cellular functions, such as cell proliferation, apoptosis, the cell cycle and DNA repair. It is …

Accumulating evidence indicates that a sub-population of cancer cells with stem-like
properties, termed tumor-initiating cells (T-ICs), exist in many different kinds of malignancies …

Sumoylation is an essential post-translational modification that has evolved to regulate
intricate networks within emerging complexities of eukaryotic cells. Thousands of target …

Tumor cell proliferation is frequently associated with genetic or epigenetic alterations in key
regulators of the cell cycle. Most known oncogenes and tumor suppressors target entry into …

SUMOylation is a post-translational modification characterized by covalent and reversible
binding of small ubiquitin-like modifier (SUMO) to a target protein. In mammals, four different …