T cell regeneration after immunological injury
Following periods of haematopoietic cell stress, such as after chemotherapy, radiotherapy,
infection and transplantation, patient outcomes are linked to the degree of immune …
infection and transplantation, patient outcomes are linked to the degree of immune …
Thymus functionality needs more than a few TECs
P Bhalla, DM Su, NSC van Oers - Frontiers in immunology, 2022 - frontiersin.org
The thymus, a primary lymphoid organ, produces the T cells of the immune system.
Originating from the 3rd pharyngeal pouch during embryogenesis, this organ functions …
Originating from the 3rd pharyngeal pouch during embryogenesis, this organ functions …
STS1 and STS2 Phosphatase Inhibitor Baicalein Enhances the Expansion of Hematopoietic and Progenitor Stem Cells and Alleviates 5-Fluorouracil-Induced …
N Li, Y Wang, A Wang, J Zhang, C Jia, C Yu… - International Journal of …, 2023 - mdpi.com
STS1 and STS2, as the protein phosphatases that dephosphorylate FLT3 and cKIT,
negatively regulate the self-renewal and differentiation of hematopoietic stem and progenitor …
negatively regulate the self-renewal and differentiation of hematopoietic stem and progenitor …
Wu-5, a novel USP10 inhibitor, enhances crenolanib-induced FLT3-ITD-positive AML cell death via inhibiting FLT3 and AMPK pathways
M Yu, Z Fang, W Wang, Y Zhang, Z Bu, M Liu… - Acta pharmacologica …, 2021 - nature.com
The kinase FLT3 internal tandem duplication (FLT3-ITD) is related to poor clinical outcomes
of acute myeloid leukemia (AML). FLT3 inhibitors have provided novel strategies for the …
of acute myeloid leukemia (AML). FLT3 inhibitors have provided novel strategies for the …
Cytokine‐induced hematopoietic stem and progenitor cell mobilization: unraveling interactions between stem cells and their niche
EJFM de Kruijf, WE Fibbe… - Annals of the New York …, 2020 - Wiley Online Library
Peripheral blood hematopoietic stem and progenitor cells (HSPCs), mobilized by
granulocyte colony‐stimulating factor, are widely used as a source for both autologous and …
granulocyte colony‐stimulating factor, are widely used as a source for both autologous and …
The potential role of the thymus in immunotherapies for acute myeloid leukemia
C Hino, Y Xu, J Xiao, DJ Baylink, ME Reeves… - Frontiers in …, 2023 - frontiersin.org
Understanding the factors which shape T-lymphocyte immunity is critical for the
development and application of future immunotherapeutic strategies in treating …
development and application of future immunotherapeutic strategies in treating …
Immune reconstitution after allogeneic haematopoietic cell transplantation: from observational studies to targeted interventions
A Yanir, A Schulz, A Lawitschka, S Nierkens… - Frontiers in …, 2022 - frontiersin.org
Immune reconstitution (IR) after allogeneic haematopoietic cell transplantation (HCT)
represents a central determinant of the clinical post-transplant course, since the majority of …
represents a central determinant of the clinical post-transplant course, since the majority of …
[HTML][HTML] Co‑transplantation of tonsil‑derived mesenchymal stromal cells in bone marrow transplantation promotes thymus regeneration and T cell diversity following …
DW Choi, KA Cho, HJ Lee, YH Kim… - International …, 2020 - spandidos-publications.com
Bone marrow (BM) transplantation (BMT) represents a curative treatment for various
hematological disorders. Prior to BMT, a large amount of the relevant anticancer drug …
hematological disorders. Prior to BMT, a large amount of the relevant anticancer drug …
Multi-objective optimization reveals time-and dose-dependent inflammatory cytokine-mediated regulation of human stem cell derived T-cell development
The generation of T-cells from stem cells in vitro could provide an alternative source of cells
for immunotherapies. T-cell development from hematopoietic stem and progenitor cells …
for immunotherapies. T-cell development from hematopoietic stem and progenitor cells …
Advances in ex vivo expansion of hematopoietic stem and progenitor cells for clinical applications
A Branco, J Rayabaram, CC Miranda… - … in Bioengineering and …, 2024 - frontiersin.org
As caretakers of the hematopoietic system, hematopoietic stem cells assure a lifelong supply
of differentiated populations that are responsible for critical bodily functions, including …
of differentiated populations that are responsible for critical bodily functions, including …