Neuromodulation of spike-timing-dependent plasticity: past, present, and future

Z Brzosko, SB Mierau, O Paulsen - Neuron, 2019 - cell.com
Spike-timing-dependent synaptic plasticity (STDP) is a leading cellular model for behavioral
learning and memory with rich computational properties. However, the relationship between …

The role of acetylcholine in learning and memory

ME Hasselmo - Current opinion in neurobiology, 2006 - Elsevier
Pharmacological data clearly indicate that both muscarinic and nicotinic acetylcholine
receptors have a role in the encoding of new memories. Localized lesions and antagonist …

Molecularly defined and functionally distinct cholinergic subnetworks

X Li, H Yu, B Zhang, L Li, W Chen, Q Yu, X Huang… - Neuron, 2022 - cell.com
Cholinergic neurons in the medial septum (MS) constitute a major source of cholinergic
input to the forebrain and modulate diverse functions, including sensory processing …

The cholinergic system and hippocampal plasticity

BD Drever, G Riedel, B Platt - Behavioural brain research, 2011 - Elsevier
Acetylcholine is an essential excitatory neurotransmitter in the central nervous system and
undertakes a vital role in cognitive function. Consequently, there is ample evidence to …

[HTML][HTML] Cholinergic modulation of cognitive processing: insights drawn from computational models

EL Newman, K Gupta, JR Climer… - Frontiers in behavioral …, 2012 - frontiersin.org
Acetylcholine plays an important role in cognitive function, as shown by pharmacological
manipulations that impact working memory, attention, episodic memory and spatial memory …

Activation of muscarinic M1 acetylcholine receptors induces long-term potentiation in the hippocampus

SH Dennis, F Pasqui, EM Colvin, H Sanger… - Cerebral …, 2016 - academic.oup.com
Muscarinic M1 acetylcholine receptors (M1Rs) are highly expressed in the hippocampus,
and their inhibition or ablation disrupts the encoding of spatial memory. It has been …

Cholinergic blockade reduces theta-gamma phase amplitude coupling and speed modulation of theta frequency consistent with behavioral effects on encoding

EL Newman, SN Gillet, JR Climer… - Journal of …, 2013 - Soc Neuroscience
Large-scale neural activation dynamics in the hippocampal-entorhinal circuit local field
potential, observable as theta and gamma rhythms and coupling between these rhythms, is …

[图书][B] How we remember: Brain mechanisms of episodic memory

ME Hasselmo - 2012 - books.google.com
Episodic memory proves essential for daily function, allowing us to remember where we
parked the car, what time we walked the dog, or what a friend said earlier. In" How We …

Sequential neuromodulation of Hebbian plasticity offers mechanism for effective reward-based navigation

Z Brzosko, S Zannone, W Schultz, C Clopath… - Elife, 2017 - elifesciences.org
Spike timing-dependent plasticity (STDP) is under neuromodulatory control, which is
correlated with distinct behavioral states. Previously, we reported that dopamine, a reward …

Normalization of HPA axis, cholinergic neurotransmission, and inhibiting brain oxidative and inflammatory dynamics are associated with the adaptogenic-like effect of …

JOT Emudainohwo, B Ben-Azu, OG Adebayo… - Journal of Molecular …, 2023 - Springer
Social defeat stress (SDS) due to changes in biochemical functions has been implicated in
the pathogenesis of affective and cognitive disorders. Employing pharmacological approach …