Tendon is a crucial component of the musculoskeletal system. Tendons connect muscle to
bone and transmit forces to produce motion. Chronic and acute tendon injuries are very …

Tendinopathy and tendon rupture are common and disabling musculoskeletal conditions.
Despite the prevalence of these injuries, a limited number of investigators are conducting …

Adult tissue repair and regeneration require stem-progenitor cells that can self-renew and
generate differentiated progeny. Skeletal muscle regenerative capacity relies on muscle …

Syncytial skeletal muscle cells contain hundreds of nuclei in a shared cytoplasm. We
investigated nuclear heterogeneity and transcriptional dynamics in the uninjured and …

To date, the cell and molecular mechanisms regulating tendon healing are poorly
understood. Here, we establish a novel model of tendon regeneration using neonatal mice …

Activins are dimeric glycoproteins belonging to the transforming growth factor beta
superfamily and resulting from the assembly of two beta subunits, which may also be …

The Role of Mechanical Loading in Tendon Development, Mainte... : JBJS The Role of
Mechanical Loading in Tendon Development, Maintenance, Injury, and Repair : JBJS JBJS …

Tendon formation and repair rely on specific combinations of transcription factors, growth
factors, and mechanical parameters that regulate the production and spatial organization of …

The musculoskeletal system evolved in mammals to perform diverse functions that include
locomotion, facilitating breathing, protecting internal organs, and coordinating global energy …

Tendons and ligaments are extracellular matrix (ECM)-rich structures that interconnect
muscles and bones. Recent work has shown how tendon fibroblasts (tenocytes) interact with …