Cellular senescence is an irreversible state of cell cycle arrest occurring in response to
stressful stimuli, such as telomere attrition, DNA damage, reactive oxygen species, and …

Byproducts of normal mitochondrial metabolism and homeostasis include the buildup of
potentially damaging levels of reactive oxygen species (ROS), Ca2+, etc., which must be …

Cardiolipin is a unique phospholipid which is almost exclusively located in the inner
mitochondrial membrane where it is biosynthesized. Considerable progress has recently …

Monogenic Mitochondrial Disorders | New England Journal of Medicine Skip to main content The
New England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES …

Parkinson's disease is a progressive neurodegenerative disease in the elderly, and no cure
or disease-modifying therapies exist. Several lines of evidence suggest that mitochondrial …

L-Tyrosine (Tyr) is an aromatic amino acid (AAA) required for protein synthesis in all
organisms, but synthesized de novo only in plants and microorganisms. In plants, Tyr also …

Manganese (Mn) is an essential dietary nutrient, but an excess or accumulation can be toxic.
Disease states, such as manganism, are associated with overexposure or accumulation of …

The reduction of oxidative stress could be achieved in three levels: by lowering exposure to
environmental pollutants with oxidizing properties, by increasing levels of endogenous and …

Plastoquinone (PQ) and ubiquinone (UQ) are two important prenylquinones, functioning as
electron transporters in the electron transport chain of oxygenic photosynthesis and the …

Alzheimer's disease (AD) is a major cause of dementia in older adults and is fast becoming
a major societal and economic burden due to an increase in life expectancy. Age seems to …