Tau is well established as a microtubule-associated protein in neurons. However, under
pathological conditions, aberrant assembly of tau into insoluble aggregates is accompanied …

Tau represents the subunit protein of one of the major hallmarks of Alzheimer disease (AD),
the neurofibrillary tangles, and is therefore of major interest as an indicator of disease …

Microtubules (MTs) play a fundamental role in many vital processes such as cell division
and neuronal activity. They are key structural and functional elements in axons, supporting …

It has long been axiomatic that a protein's structure determines its function. Intrinsically
disordered proteins (IDPs) and disordered protein regions (IDRs) defy this structure …

Tau protein is abundant in the central nervous system and involved in microtubule assembly
and stabilization. It is predominantly associated with axonal microtubules and present at …

Tau is a microtubule-associated protein with versatile functions in the dynamic assembly of
the neuronal cytoskeleton. Four-repeat (4R-) tauopathies are a group of neurodegenerative …

Alzheimer disease is characterized by abnormal protein deposits in the brain, such as
extracellular amyloid plaques and intracellular neurofibrillary tangles. The tangles are made …

The abnormal aggregation of the microtubule-associated protein Tau into paired helical
filaments (PHFs) is one of the hallmarks of Alzheimer disease (AD). Tau in solution behaves …

Cellular condensation of intrinsically disordered proteins (IDPs) through liquid–liquid phase
separation (LLPS) allows dynamic compartmentalization and regulation of biological …

Microtubule-associated Tau proteins belong to a family of factors that polymerize tubulin
dimers and stabilize microtubules. Tau is strongly expressed in neurons, localized in the …