Over decades, researchers have focused on the epigenetic control of DNA-templated
processes. Histone modification, DNA methylation, chromatin remodeling, RNA modification …

Dysregulation of the epigenome drives aberrant transcriptional programmes that promote
cancer onset and progression. Although defective gene regulation often affects oncogenic …

Vitamin C (ascorbate) is maintained at high levels in most immune cells and can affect many
aspects of the immune response. Intracellular levels generally respond to variations in …

Bladder cancer is lethal in its advanced, muscle-invasive phase with very limited therapeutic
advances,. Recent molecular characterization has defined new (epi) genetic drivers and …

The innate immune response is a rapid response to pathogens or danger signals. It is
precisely activated not only to efficiently eliminate pathogens but also to avoid excessive …

Rationale: As the central hallmark of liver fibrosis, transdifferentiation of hepatic stellate cells
(HSCs), the predominant contributor to fibrogenic hepatic myofibroblast responsible for …

Atherosclerosis, the principal cause of cardiovascular death worldwide, is a pathological
disease characterized by fibro-proliferation, chronic inflammation, lipid accumulation, and …

In recent years, many studies have shown that histone methylation plays an important role in
maintaining the active and silent state of gene expression in human diseases. The Jumonji …

Abstract Histone 3 lysine 27 (H3K27) demethylation constitutes an important epigenetic
mechanism of gene activation. It is mediated by the Jumonji C domain-containing lysine …

Silencing of the somatic cell type-specific genes is a critical yet poorly understood step in
reprogramming. To uncover pathways that maintain cell identity, we performed a …