Adherens junctions as molecular regulators of emergent tissue mechanics

O Campàs, I Noordstra, AS Yap - Nature Reviews Molecular Cell …, 2024 - nature.com
Tissue and organ development during embryogenesis relies on the collective and
coordinated action of many cells. Recent studies have revealed that tissue material …

Mechanochemical feedback loops in development and disease

E Hannezo, CP Heisenberg - Cell, 2019 - cell.com
There is increasing evidence that both mechanical and biochemical signals play important
roles in development and disease. The development of complex organisms, in particular …

The nucleus measures shape changes for cellular proprioception to control dynamic cell behavior

V Venturini, F Pezzano, F Catala Castro, HM Häkkinen… - Science, 2020 - science.org
INTRODUCTION Human beings are equipped with multiple senses (sight, hearing, smell,
taste, touch, and proprioception) to help them to react properly to their environment. The …

Cell and nucleus shape as an indicator of tissue fluidity in carcinoma

S Grosser, J Lippoldt, L Oswald, M Merkel… - Physical Review X, 2021 - APS
Tissue, cell, and nucleus morphology change during tumor progression. In 2D confluent cell
cultures, different tissue states, such as fluid (unjammed) and solid (jammed), are correlated …

[HTML][HTML] The mechanics of mitotic cell rounding

AV Taubenberger, B Baum… - Frontiers in cell and …, 2020 - frontiersin.org
When animal cells enter mitosis, they round up to become spherical. This shape change is
accompanied by changes in mechanical properties. Multiple studies using different …

Long noncoding RNA LINC00662 promotes M2 macrophage polarization and hepatocellular carcinoma progression via activating Wnt/β‐catenin signaling

X Tian, Y Wu, Y Yang, J Wang, M Niu, S Gao… - Molecular …, 2020 - Wiley Online Library
Tumor‐associated macrophages have important roles in hepatocellular carcinoma (HCC)
initiation and progression. Long noncoding RNAs (lncRNAs) have also been reported to be …

Embryonic tissues as active foams

S Kim, M Pochitaloff, GA Stooke-Vaughan, O Campàs - Nature physics, 2021 - nature.com
The physical state of embryonic tissues emerges from non-equilibrium, collective
interactions among constituent cells. Cellular jamming, rigidity transitions and characteristics …

Tissue fluidity promotes epithelial wound healing

RJ Tetley, MF Staddon, D Heller, A Hoppe, S Banerjee… - Nature physics, 2019 - nature.com
The collective behaviour of cells in epithelial tissues is dependent on their mechanical
properties. However, the contribution of tissue mechanics to wound healing in vivo remains …

Rigidity percolation uncovers a structural basis for embryonic tissue phase transitions

NI Petridou, B Corominas-Murtra, CP Heisenberg… - Cell, 2021 - cell.com
Embryo morphogenesis is impacted by dynamic changes in tissue material properties,
which have been proposed to occur via processes akin to phase transitions (PTs). Here, we …

Morphogens enable interacting supracellular phases that generate organ architecture

S Yang, KH Palmquist, L Nathan, CR Pfeifer… - Science, 2023 - science.org
During vertebrate organogenesis, increases in morphological complexity are tightly coupled
to morphogen expression. In this work, we studied how morphogens influence self …