The abnormal regulation of alternative splicing is usually accompanied by the occurrence
and development of tumors, which would produce multiple different isoforms and diversify …

Long non-coding RNA (lncRNA) was originally defined as the representative of the non-
coding RNAs and unable to encode. However, recent reports suggest that some lncRNAs …

Acute myeloid leukemia (AML) is a hematopoietic malignancy with poor prognosis and
limited treatment options. Here we provide a comprehensive census of the bone marrow …

Initiation is the rate-limiting step in translation, and its dysregulation is vital for
carcinogenesis, including hematopoietic malignancy. Thus, discovery of novel translation …

Since the introduction of the central dogma of molecular biology in 1958, various RNA
species have been discovered. Messenger RNAs transmit genetic instructions from DNA to …

Hematologic malignancies are one of the most common cancers, and the incidence has
been rising in recent decades. The clinical and molecular features of hematologic …

Increasing evidence has indicated that long noncoding RNAs (lncRNAs) play various
important roles in the development of cancers. The widespread applications of ribosome …

Alternative splicing (AS) of RNA molecules is a key contributor to transcriptome diversity. In
humans, 90%–95% of multi-exon genes produce alternatively spliced RNA transcripts …

Improving the chemotherapy resistance of temozolomide (TMZ) is of great significance in the
treatment of glioblastoma multiforme (GBM). Long non‐coding RNA just proximal to the X …

Next-generation sequencing (NGS) technologies have greatly expanded the size of the
known transcriptome. Many newly discovered transcripts are classified as long noncoding …