Glioblastoma (GBM) is a devastating type of brain tumor, and current therapeutic treatments,
including surgery, chemotherapy, and radiation, are palliative at best. The design of effective …

In patients with glioblastoma, the average survival time with current treatments is short,
mainly due to recurrences and resistance to therapy. This insufficient treatment success is, in …

Cancer cells support their growth and proliferation by reprogramming their metabolism in
order to gain access to nutrients. Despite the heterogeneity in genetic mutations that lead to …

Continuous proliferation of tumor cells requires constant adaptations of energy metabolism
to rapidly fuel cell growth and division. This energetic adaptation often comprises …

Discovery of point mutations in the genes encoding isocitrate dehydrogenases (IDH) in
gliomas about a decade ago has challenged our view of the role of metabolism in tumor …

Purpose: Telomere maintenance is a hallmark of cancer. Most tumors maintain telomere
length via reactivation of telomerase reverse transcriptase (TERT) expression. Identifying …

Simple Summary Chondrosarcomas are cartilage tumours that often harbour a mutation in
one of the isocitrate dehydrogenase (IDH) genes. IDH mutations are important drivers at the …

Brain tumours are the leading cause of paediatric cancer-associated death worldwide. High-
grade glioma (HGG) represents a main cause of paediatric brain tumours and is associated …

Purpose: Mutations of the isocitrate dehydrogenase (IDH) gene are common genetic
mutations in human malignancies. Increasing evidence indicates that IDH mutations play …

Simple Summary IDH mutation is one of the most important prognostic biomarkers in glioma
management. Noninvasive neuroimaging techniques to predict IDH mutant glioma may be …