Oxidative stress has long been implicated in cardiovascular disease, but more recently, the
role of reactive oxygen species (ROS) in normal physiological signaling has been …

It has been known for more than 60 years, and suspected for over 100, that alveolar hypoxia
causes pulmonary vasoconstriction by means of mechanisms local to the lung. For the last …

Hypomagnesemia is commonly observed in heart failure, diabetes mellitus, hypertension,
and cardiovascular diseases. Low serum magnesium (Mg) is a predictor for cardiovascular …

In the past five years, skeletal muscle has emerged as a paradigm of “nitric oxide”(NO)
function and redox-related signaling in biology. All major nitric oxide synthase (NOS) …

The nervous system senses peripheral damage through nociceptive neurons that transmit a
pain signal,. TRPA1 is a member of the Transient Receptor Potential (TRP) family of ion …

cellular apoptosis signaling kinase-1, a redox-sensitive kinase upstream of Jun-nuclear
kinase and p38. Apoptosis signaling kinase-1 overexpression activates nuclear factor κB to …

Intracellular concentrations of redox-active molecules can significantly increase in the heart
as a result of activation of specific signal transduction pathways or the development of …

Patients with heart failure experience a number of changes in the electrical function of the
heart that predispose to potentially lethal cardiac arrhythmias. Action potential prolongation …

▪ Abstract O2 sensing is a fundamental biological process necessary for adaptation of living
organisms to variable habitats and physiological situations. Cellular responses to hypoxia …

Cardiac arrhythmias can cause sudden cardiac death (SCD) and add to the current heart
failure (HF) health crisis. Nevertheless, the pathological processes underlying arrhythmias …